Title:
EPH RECEPTOR AND EPHRIN LIGAND SPECIFIC VHH ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2010/066835
Kind Code:
A3
Abstract:
The present invention relates to amino acid sequences that are directed against proteins from the group of the Eph receptor family such as EphA1 to EphA10, EphB1 to EphB6 and Ephrin ligands such as EphrinA1 to EphrinA6 and EprhinB1 to EphrinB3 as well as to constructs that comprise or essentially consist of one or more of such amino acid sequences.
Inventors:
BLANCHETOT CHRISTOPH (NL)
SAUNDERS MICHAEL JOHN SCOTT (BE)
DE HAARD JOHANNES JOSEPH WILHELMUS (NL)
VANLANDSCHOOT PETER (BE)
SAUNDERS MICHAEL JOHN SCOTT (BE)
DE HAARD JOHANNES JOSEPH WILHELMUS (NL)
VANLANDSCHOOT PETER (BE)
Application Number:
PCT/EP2009/066821
Publication Date:
January 13, 2011
Filing Date:
December 10, 2009
Export Citation:
Assignee:
ABLYNX NV (BE)
BLANCHETOT CHRISTOPH (NL)
SAUNDERS MICHAEL JOHN SCOTT (BE)
DE HAARD JOHANNES JOSEPH WILHELMUS (NL)
VANLANDSCHOOT PETER (BE)
BLANCHETOT CHRISTOPH (NL)
SAUNDERS MICHAEL JOHN SCOTT (BE)
DE HAARD JOHANNES JOSEPH WILHELMUS (NL)
VANLANDSCHOOT PETER (BE)
International Classes:
C07K16/28
Domestic Patent References:
| WO2006023403A2 | 2006-03-02 | |||
| WO2006047298A2 | 2006-05-04 |
Other References:
ANONYMOUS: "Product details for anti-EphA1 antibody", 2007, XP002580838, Retrieved from the Internet [retrieved on 20100503]
ANONYMOUS: "Developmental & Neuroscience Research ReagentsIn Scope", November 2001 (2001-11-01), XP002580839, Retrieved from the Internet [retrieved on 20100503]
ANONYMOUS: "Monoclonal Anti-human EphA1 Antibody", 13 August 2003 (2003-08-13), XP002580840, Retrieved from the Internet [retrieved on 20100503]
GOLDSHMIT Y ET AL: "Roles of Eph receptors and ephrins in the normal and damaged adult CNS", BRAIN RESEARCH REVIEWS, ELSEVIER, NL LNKD- DOI:10.1016/J.BRAINRESREV.2006.04.006, vol. 52, no. 2, 1 September 2006 (2006-09-01), pages 327 - 345, XP024996734, ISSN: 0165-0173, [retrieved on 20060901]
DANA M BRANTLEY-SIEDERS ET AL: "Eph Receptor Tyrosine Kinases in Angiogenesis: From Development to Disease", ANGIOGENESIS, KLUWER ACADEMIC PUBLISHERS, DO LNKD- DOI:10.1023/B:AGEN.0000037340.33788.87, vol. 7, no. 1, 1 March 2004 (2004-03-01), pages 17 - 28, XP019226874, ISSN: 1573-7209
COULTHARD M G ET AL: "Characterization of the Epha1 receptor tyrosine kinase: expression in epithelial tissues.", GROWTH FACTORS (CHUR, SWITZERLAND) 2001 LNKD- PUBMED:11519828, vol. 18, no. 4, 2001, pages 303 - 317, XP009133067, ISSN: 0897-7194
ANONYMOUS: "Developmental & Neuroscience Research ReagentsIn Scope", November 2001 (2001-11-01), XP002580839, Retrieved from the Internet
ANONYMOUS: "Monoclonal Anti-human EphA1 Antibody", 13 August 2003 (2003-08-13), XP002580840, Retrieved from the Internet
GOLDSHMIT Y ET AL: "Roles of Eph receptors and ephrins in the normal and damaged adult CNS", BRAIN RESEARCH REVIEWS, ELSEVIER, NL LNKD- DOI:10.1016/J.BRAINRESREV.2006.04.006, vol. 52, no. 2, 1 September 2006 (2006-09-01), pages 327 - 345, XP024996734, ISSN: 0165-0173, [retrieved on 20060901]
DANA M BRANTLEY-SIEDERS ET AL: "Eph Receptor Tyrosine Kinases in Angiogenesis: From Development to Disease", ANGIOGENESIS, KLUWER ACADEMIC PUBLISHERS, DO LNKD- DOI:10.1023/B:AGEN.0000037340.33788.87, vol. 7, no. 1, 1 March 2004 (2004-03-01), pages 17 - 28, XP019226874, ISSN: 1573-7209
COULTHARD M G ET AL: "Characterization of the Epha1 receptor tyrosine kinase: expression in epithelial tissues.", GROWTH FACTORS (CHUR, SWITZERLAND) 2001 LNKD- PUBMED:11519828, vol. 18, no. 4, 2001, pages 303 - 317, XP009133067, ISSN: 0897-7194
Attorney, Agent or Firm:
WIEDEMANN, P. et al. (Arabellastrasse 4, München, DE)
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