Title:
EPIDERMAL SKIN HEALTH
Document Type and Number:
WIPO Patent Application WO/2016/120341
Kind Code:
A3
Abstract:
The present invention provides methods and compositions for treating or preventing skin cancer, in particular melanoma, parakeratosis, improving the skin integrity, the skin barrier function and/or decreasing skin ageing in a mammalian subject, preferably a human subject, the method comprising applying vitamin K1, vitamin K2, Matrix Gla-Protein (MGP) or at least one bioactive peptide derived from MGP in an effective amount to the skin. Preferably, the vitamin K comprises at least one of the long-chain menaquinones MK-7 through MK-10. Preferably, the MGP-derived peptides contain the uncarboxylated Gla-domain of human MGP.
Inventors:
VERMEER CORNELIS (NL)
Application Number:
PCT/EP2016/051724
Publication Date:
September 22, 2016
Filing Date:
January 27, 2016
Export Citation:
Assignee:
VITAK BV (NL)
International Classes:
A61K8/64; A61K8/67; A61Q19/00; A61Q19/08
Domestic Patent References:
| WO2012000930A1 | 2012-01-05 | |||
| WO2002002764A2 | 2002-01-10 | |||
| WO2009063485A2 | 2009-05-22 | |||
| WO2006113479A2 | 2006-10-26 | |||
| WO2014017145A1 | 2014-01-30 |
Foreign References:
| US20100247693A1 | 2010-09-30 | |||
| EP2561869A1 | 2013-02-27 |
Other References:
SCHURGERS LEON J ET AL: "Matrix Gla-protein: The calcification inhibitor in need of vitamin K", THROMBOSIS AND HAEMOSTASIS, SCHATTAUER GMBH, DE, vol. 100, 1 October 2008 (2008-10-01), pages 593 - 603, XP002657395, ISSN: 0340-6245, [retrieved on 20080905], DOI: 10.1160/TH08-02-0087
Attorney, Agent or Firm:
HUYGENS, Arthur (P.O. Box 86, 3400 AB IJsselstein, NL)
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