Title:
EPITOPE MODIFICATION
Document Type and Number:
WIPO Patent Application WO/2023/025147
Kind Code:
A1
Abstract:
The present invention relates to epitope modification based on a chemical crosslinking group and the use thereof in changing the immunogenicity of an antigen and increasing animal immune response to a target epitope of an antigen. The present invention relates to the administration of a mutant antigen formed by means of incorporating a group or derivative thereof having a chemical crosslinking activity into a wild-type target epitope to an animal, wherein the antibody reaction in the animal is directed and enriched to the target epitope by the mutant antigen. Provided are a method for screening an antibody against a target epitope of an antigen and the antibody obtained thereby; further provided is the use of the method in the preparation of a vaccine for preventing and treating diseases.
Inventors:
WANG FENG (CN)
ZHU CHAOYANG (CN)
XU LIANG (CN)
ZHU CHAOYANG (CN)
XU LIANG (CN)
Application Number:
PCT/CN2022/114250
Publication Date:
March 02, 2023
Filing Date:
August 23, 2022
Export Citation:
Assignee:
NANTONG YICHEN BIOPHARMA CO LTD (CN)
International Classes:
A61K39/00; A61K39/395; C07K1/107
Foreign References:
| CN101970005A | 2011-02-09 | |||
| CN109172820A | 2019-01-11 | |||
| CN111662381A | 2020-09-15 | |||
| CN1168674A | 1997-12-24 | |||
| US20020168383A1 | 2002-11-14 | |||
| EP0783892B1 | 2002-07-03 |
Other References:
CHEN LONGXIN, ZHU CHAOYANG, GUO HUI, LI RUNTING, ZHANG LIMENG, XING ZHENZHEN, SONG YUE, ZHANG ZIHAN, WANG FUPING, LIU XIAOFENG, Z: "Epitope-directed antibody selection by site-specific photocrosslinking", SCI. ADV, 1 January 2020 (2020-01-01), XP093010589, Retrieved from the Internet [retrieved on 20221222], DOI: 10.1126/sciadv.aaz7825
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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