Title:
ERECTILE DYSFUNCTION THERAPEUTIC AGENT
Document Type and Number:
WIPO Patent Application WO/2019/163798
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel therapeutic strategy against erectile dysfunction. Disclosed is an erectile dysfunction therapeutic agent that contains a filtrate obtained by filtering a liquid of disrupted fat-tissue-derived stem cells or disrupted bone-marrow-derived stem cells.
Inventors:
MATSUMOTO SEIJI (JP)
YAMAMOTO TOKUNORI (JP)
HOTTA YUJI (JP)
KIMURA KAZUNORI (JP)
YAMAMOTO TOKUNORI (JP)
HOTTA YUJI (JP)
KIMURA KAZUNORI (JP)
Application Number:
PCT/JP2019/006205
Publication Date:
August 29, 2019
Filing Date:
February 20, 2019
Export Citation:
Assignee:
NATIONAL UNIV CORPORATION ASAHIKAWA MEDICAL UNIV (JP)
International Classes:
A61K35/28; A61K35/35; A61K45/00; A61P15/10
Domestic Patent References:
| WO1998053819A1 | 1998-12-03 | |||
| WO2000033845A1 | 2000-06-15 | |||
| WO1999043674A1 | 1999-09-02 | |||
| WO2006006692A1 | 2006-01-19 |
Foreign References:
| US20160008402A1 | 2016-01-14 | |||
| JP2018031340A | 2018-03-01 |
Other References:
CHEN FENGZHI ET AL.: "Adipose-derived stem cell -derived exosomes ameliorate erectile dysfunction in a rat model of type 2 diabetes", THE JOURNAL OF SEXUAL MEDICINE, vol. 14, no. 9, 2017, pages 1084 - 1094, XP009513263, doi:10.1016/j.jsxm.2017.07.005
ALBERSEN MAARTEN ET AL.: "Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury", THE JOURNAL OF SEXUAL MEDICINE, vol. 7, no. 10, 2010, pages 3331 - 3340, XP055631749
GRANT RYAN ET AL.: "A filtration-based protocol to isolate human plasma membrane-derived vesicles and exosomes from blood plasma", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 371, no. 1-2, 2011, pages 143 - 151, XP028254111, doi:10.1016/j.jim.2011.06.024
NISHIMATSU HIROAKI ET AL.: "Adrenomedullin mediates adipose tissue-derived stem cell-induced restoration of erectile function in diabetic rats", THE JOURNAL OF SEXUAL MEDICINE, vol. 9, no. 2, 2012, pages 482 - 493, XP055631758
AYTA IAMCKINLAY JBKRANE RJ.: "The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences", BJU INT, vol. 84, 1999, pages 50 - 56
ALBERSEN MFANDEL TMLIN GWANG GBANIE LLIN CSLUE TF.: "Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury", J SEX MED, vol. 7, no. 10, 2010, pages 3331 - 40, XP055631749, DOI: 10.1111/j.1743-6109.2010.01875.x
FRASER JK ET AL.: "Fat tissue:an underappreciated source of stem cells for biotechnology", TRENDS IN BIOTECHNOLOGY, vol. 24, no. 4, April 2006 (2006-04-01), pages 150 - 4, XP025052292, DOI: 10.1016/j.tibtech.2006.01.010
ZUK PA ET AL.: "Human adipose tissue is a source of multipotent stem cells", MOLECULAR BIOLOGY OF THE CELL, vol. 13, no. 12, December 2002 (2002-12-01), pages 4279 - 95, XP002249630, DOI: 10.1091/mbc.E02-02-0105
ZUK PA ET AL.: "Multilineage cells from human adipose tissue:implications for cell-based therapies", TISSUE ENGINEERING, vol. 7, no. 2, April 2001 (2001-04-01), pages 211 - 28, XP002746115, DOI: 10.1089/107632701300062859
R.I. FRESHNEY: "Culture of Animal Cells:A Manual of Basic Technique", JOHN WILEY
See also references of EP 3756677A4
ALBERSEN MAARTEN ET AL.: "Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury", THE JOURNAL OF SEXUAL MEDICINE, vol. 7, no. 10, 2010, pages 3331 - 3340, XP055631749
GRANT RYAN ET AL.: "A filtration-based protocol to isolate human plasma membrane-derived vesicles and exosomes from blood plasma", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 371, no. 1-2, 2011, pages 143 - 151, XP028254111, doi:10.1016/j.jim.2011.06.024
NISHIMATSU HIROAKI ET AL.: "Adrenomedullin mediates adipose tissue-derived stem cell-induced restoration of erectile function in diabetic rats", THE JOURNAL OF SEXUAL MEDICINE, vol. 9, no. 2, 2012, pages 482 - 493, XP055631758
AYTA IAMCKINLAY JBKRANE RJ.: "The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences", BJU INT, vol. 84, 1999, pages 50 - 56
ALBERSEN MFANDEL TMLIN GWANG GBANIE LLIN CSLUE TF.: "Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury", J SEX MED, vol. 7, no. 10, 2010, pages 3331 - 40, XP055631749, DOI: 10.1111/j.1743-6109.2010.01875.x
FRASER JK ET AL.: "Fat tissue:an underappreciated source of stem cells for biotechnology", TRENDS IN BIOTECHNOLOGY, vol. 24, no. 4, April 2006 (2006-04-01), pages 150 - 4, XP025052292, DOI: 10.1016/j.tibtech.2006.01.010
ZUK PA ET AL.: "Human adipose tissue is a source of multipotent stem cells", MOLECULAR BIOLOGY OF THE CELL, vol. 13, no. 12, December 2002 (2002-12-01), pages 4279 - 95, XP002249630, DOI: 10.1091/mbc.E02-02-0105
ZUK PA ET AL.: "Multilineage cells from human adipose tissue:implications for cell-based therapies", TISSUE ENGINEERING, vol. 7, no. 2, April 2001 (2001-04-01), pages 211 - 28, XP002746115, DOI: 10.1089/107632701300062859
R.I. FRESHNEY: "Culture of Animal Cells:A Manual of Basic Technique", JOHN WILEY
See also references of EP 3756677A4
Attorney, Agent or Firm:
HAGINO Mikiharu (JP)
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