Title:
ERYTHROMYCIN DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1993/024509
Kind Code:
A1
Abstract:
A compound represented by general formula [I] or a salt thereof, being extremely reduced in the decomposability by gastric juice as compared with other known erythromycin derivatives and having an excellent activity of promoting the movement of digestive tracts, wherein R1 represents hydrogen or acyl; R2 and R3 may be the same or different from each other and each represents hydrogen, hydroxy, acyloxy or amino, or alternatively R2 and R3 are combined together to represent =O or =NOR10, wherein R10 represents hydrogen or lower alkyl; R4 represents hydrogen or lower alkyl; and Y represents -NR5R6 or -N+R7R8R9X-, wherein R5, R6, R7, R8 and R9 may be the same or different from one another and each represents hydrogen, optionally substituted lower alkyl, lower alkenyl, lower alkynyl or cycloalkyl, or a 3- to 7-membered heterocyclic group containing oxygen, nitrogen or sulfur as the heteroatom, and X represents an anion, provided that a pair of R5 and R6 and a pair of R7 and R8 may be each combined with the adjacent nitrogen atom to represent azacycloalkyl.
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Inventors:
KOGA HIROSHI (JP)
SATO TSUTOMU (JP)
TAKANASHI HISANORI (JP)
SATO TSUTOMU (JP)
TAKANASHI HISANORI (JP)
Application Number:
PCT/JP1993/000702
Publication Date:
December 09, 1993
Filing Date:
May 26, 1993
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
KOGA HIROSHI (JP)
SATO TSUTOMU (JP)
TAKANASHI HISANORI (JP)
KOGA HIROSHI (JP)
SATO TSUTOMU (JP)
TAKANASHI HISANORI (JP)
International Classes:
A61K31/70; A61K31/7042; C07H17/08; A61K31/7048; A61P1/00; A61P1/12; A61P43/00; A61K31/00; C07D407/00; (IPC1-7): C07H17/08
Foreign References:
| JPS6399092A | 1988-04-30 | |||
| JPS6399016A | 1988-04-30 |
Other References:
Chemical & Pharmaceutical Bulletin, Vol. 37 (No. 10), pp. 2678-2700 (1989), K. TSUZUKI et al., "Motilides, Macrolides with Gastroin Testinal Motor Stimulating Activity I".
Chemical & Pharmaceutical Bulletin, Vol. 37 (No. 19), pp. 2701-2709 (1989), K. TSUZUKI et al., "Motilides, Macrolides with Gastroin Testinal Motor Stimulating Activity II".
See also references of EP 0643068A4
Chemical & Pharmaceutical Bulletin, Vol. 37 (No. 19), pp. 2701-2709 (1989), K. TSUZUKI et al., "Motilides, Macrolides with Gastroin Testinal Motor Stimulating Activity II".
See also references of EP 0643068A4
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