Title:
ERYTHROPOIETIN-PRODUCING ORGANOID PRECURSOR, METHOD OF CONSTRUCTING THE SAME AND METHOD OF TREATING ERYTHROPOIETIN-RELATED DISEASE
Document Type and Number:
WIPO Patent Application WO/2008/004598
Kind Code:
A1
Abstract:
It is intended to provide a technique of constructing an erythropoietin-producing organoid with the use of mesenchymal stem cells originating in a mammal. A method of constructing an erythropoietin-producing organoid (organ-like structure) precursor which comprises transplanting mesenchymal stem cells originating in a mammal into a fetus within a pregnant mammalian host or a fetus separated from a pregnant mammalian host to thereby induce the differentiation of the mesenchymal stem cells. In particular, the mesenchymal stem cells are transplanted at the nephrogenous site of the fetus and the transplantation is carried out when the immune system of the host is still in the immunological tolerance stage.
Inventors:
YOKOO, Takashi (3-25-8 Nishi-Shimbashi, Minato-k, Tokyo 61, 1058461, JP)
横尾 隆 (〒61 東京都港区西新橋３－２５－８ 東京慈恵会医科大学内 Tokyo, 1058461, JP)
OKABE, Masataka (3-25-8 Nishi-Shimbashi, Minato-k, Tokyo 61, 1058461, JP)
横尾 隆 (〒61 東京都港区西新橋３－２５－８ 東京慈恵会医科大学内 Tokyo, 1058461, JP)
OKABE, Masataka (3-25-8 Nishi-Shimbashi, Minato-k, Tokyo 61, 1058461, JP)
Application Number:
JP2007/063400
Publication Date:
January 10, 2008
Filing Date:
July 04, 2007
Export Citation:
Assignee:
STEMCELL INSTITUTE INC. (5-22-10, Shimbashi Minato-k, Tokyo 04, 1050004, JP)
株式会社ステムセル研究所 (〒04 東京都港区新橋５－２２－１０ Tokyo, 1050004, JP)
YOKOO, Takashi (3-25-8 Nishi-Shimbashi, Minato-k, Tokyo 61, 1058461, JP)
横尾 隆 (〒61 東京都港区西新橋３－２５－８ 東京慈恵会医科大学内 Tokyo, 1058461, JP)
株式会社ステムセル研究所 (〒04 東京都港区新橋５－２２－１０ Tokyo, 1050004, JP)
YOKOO, Takashi (3-25-8 Nishi-Shimbashi, Minato-k, Tokyo 61, 1058461, JP)
横尾 隆 (〒61 東京都港区西新橋３－２５－８ 東京慈恵会医科大学内 Tokyo, 1058461, JP)
International Classes:
C12N5/00; A61K38/22; A61P1/04; A61P3/10; A61P7/06; A61P13/12; C12N5/06; C12N15/09
Attorney, Agent or Firm:
SHOJI, Takashi (6F SN Iwamotocho Bldg, 2-10 Iwamotocho 3-chome, Chiyoda-k, Tokyo 32, 10100, JP)
Download PDF:
Previous Patent: ANTIBACTERIAL COMPOSITION AND METHOD FOR CONTROL OF PLANT DISEASE
Next Patent: METHOD OF SEPARATING MIXED PLASTIC
Next Patent: METHOD OF SEPARATING MIXED PLASTIC