Title:
ESCAPE MUTANTS OF NEWCASTLE DISEASE VIRUS AS MARKER VACCINES
Document Type and Number:
WIPO Patent Application WO2004052278
Kind Code:
A3
Abstract:
A vaccine against Newcastle Disease contains one or more mutant immunogens of the NDW strain. The mutant immunogen lacks the antigenic binding site on the F glycoprotein which is recognized by the monoclonal antibody mAb 54. Reagent kits and assay methods help to distinguish vaccinated members of a poultry flock from those that may have been infected with wild-type Newcastle Disease virus.
Inventors:
GEERLIGS HARMEN J (NL)
BROWN IAN HAMER (GB)
ALEXANDER DENNIS JOHN (GB)
COLLINS MICHAEL SINCLAIR (GB)
BROWN IAN HAMER (GB)
ALEXANDER DENNIS JOHN (GB)
COLLINS MICHAEL SINCLAIR (GB)
Application Number:
PCT/US2003/038414
Publication Date:
September 16, 2004
Filing Date:
December 03, 2003
Export Citation:
Assignee:
WYETH CORP (US)
GEERLIGS HARMEN J (NL)
BROWN IAN HAMER (GB)
ALEXANDER DENNIS JOHN (GB)
COLLINS MICHAEL SINCLAIR (GB)
GEERLIGS HARMEN J (NL)
BROWN IAN HAMER (GB)
ALEXANDER DENNIS JOHN (GB)
COLLINS MICHAEL SINCLAIR (GB)
International Classes:
A61K6/00; A61K39/12; A61K39/17; C07K14/125; C07K16/10; C12N7/00; C12N7/02; C12N7/04; C12N7/08; C12Q1/70; A61K; (IPC1-7): A61K39/17; C12N7/08; C12N7/02; C07K16/10
Domestic Patent References:
| WO2002036617A2 | 2002-05-10 |
Foreign References:
| US5149530A | 1992-09-22 |
Other References:
YUSOFF K. ET AL: "Location of neutralizing epitopes on the fusion protein of Necastle disease virus strain beaudette C", J. GEN. VIROL., vol. 70, 1989, pages 3105 - 3109, XP002930879
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