Title:
ESCHERICHIA COLI CAPABLE OF PRODUCING 3-AMINO-4-HYDROXYBENZOIC ACID
Document Type and Number:
WIPO Patent Application WO/2013/129001
Kind Code:
A1
Abstract:
The present invention provides a method for the simple and inexpensive production of amino-hydroxybenzoic acids such as 3-amino-4-hydroxybenzoic acid using Escherichia coli, which is a bacterium that is commonly used in biosynthetic preparation processes. Specifically, the present invention provides Escherichia coli bacteria capable of producing 3-amino-4-hydroxybenzoic acid, said bacteria having been modified so as to reduce the activity of N-hydroxyarylamine O-acetyltransferase (NhoA), and a method for the production of 3-amino-4-hydroxybenzoic acids using Escherichia coli bacteria modified in this manner.
Inventors:
SHOZUI FUMI (JP)
TAJIMA YOSHINORI (JP)
TAJIMA YOSHINORI (JP)
Application Number:
PCT/JP2013/051778
Publication Date:
September 06, 2013
Filing Date:
January 28, 2013
Export Citation:
Assignee:
AJINOMOTO KK (JP)
International Classes:
C12N1/21; C08G73/22; C12P13/00; C12N15/09
Domestic Patent References:
| WO2010005099A1 | 2010-01-14 | |||
| WO2010005099A1 | 2010-01-14 | |||
| WO1991001304A1 | 1991-02-07 |
Foreign References:
| JP2008029325A | 2008-02-14 | |||
| JP2004283163A | 2004-10-14 | |||
| JP2004283163A | 2004-10-14 | |||
| US6303383B1 | 2001-10-16 | |||
| JPH057491A | 1993-01-19 | |||
| US5142021A | 1992-08-25 | |||
| US5219981A | 1993-06-15 | |||
| US5422416A | 1995-06-06 |
Other References:
SUZUKI, HIROKAZU ET AL.: "Novel benzene ring biosynthesis from C(3) and C(4) primary metabolites by two enzymes", J. BIOL. CHEM., vol. 281, no. 48, 2006, pages 36944 - 36951, XP008146388
NOGUCHI, AKIO ET AL.: "A copper-containing oxidase catalyzes C-nitrosation in nitrosobenzamide biosynthesis", NAT. CHEM. BIOL., vol. 6, 2010, pages 641 - 643, XP055154720
SIKORA, ALISON L. ET AL.: "Kinetic and chemical mechanism of arylamine N-acetyltransferase from Mycobacterium tuberculosis", BIOCHEMISTRY, vol. 47, 2008, pages 10781 - 10789, XP055154723
DATABASE GENBANK [online] 30 November 2006 (2006-11-30), XP003033756, Database accession no. AB259663.1
DATABASE GENBANK [online] 25 May 2010 (2010-05-25), XP003033757, Database accession no. AB530136.1
See also references of EP 2821479A4
J. BIOL. CHEM., vol. 281, 2006, pages 36944 - 36951
J. BACTERIOL., vol. 189, 2007, pages 2155 - 2159
BIOCHIM. BIOPHYS. ACTA, vol. 1475, 2000, pages 10 - 16
J. ANTIBIOT., vol. 59, 2006, pages 464
J. BIOL. CHEM., vol. 272, no. 13, 1997, pages 8611 - 7
PROC. NATL. ACAD. SCI. USA., vol. 97, no. 12, 6 June 2000 (2000-06-06), pages 6640 - 5
KARLIN; ALTSCHUL, PRO. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873
PEARSON, METHODS ENZYMOL., vol. 183, 1990, pages 63
JOURNAL OF BIOCHEMISTRY, vol. 281, no. 48, pages 36944 - 36951
CADWELL, R. C, PCR METH. APPL., vol. 2, 1992, pages 28
STEMMER, W. P., NATURE, vol. 370, 1994, pages 389
ZHAO, H., NATURE BIOTECHNOL., vol. 16, 1998, pages 258
SUZUKI ET AL., J. BIO. CHEM., vol. 281, 2006, pages 823 - 833
KIKUCHI ET AL., FEMS MICROBIOLOGY LETTERS, vol. 173, 1999, pages 211 - 215
FALCO ET AL., BIOTECHNOLOGY, vol. 13, 1995, pages 577 - 582
GENE, vol. 39, 1985, pages 281 - 286
BIO/TECHNOLOGY, vol. 7, 1989, pages 1067 - 1070
KRICHELDORF, MAKROMOL. CHEM., vol. 193, 1992, pages 2467 - 2476
MARCOS-FERNANDEZ, POLYMER, vol. 42, 2001, pages 7933 - 7941
SUZUKI, J. BACTERIOL., vol. 189, 2007, pages 2155 - 2159
KESELER ET AL., NUCLEIC ACIDS RES., vol. 33, 2005, pages 334 - 337, Retrieved from the Internet
HALDIMANN, J. BACTERIOL., vol. 183, 2001, pages 6384 - 6393
BABA, MOL. SYST. BIOL., vol. 2, 2006, pages 2006 - 2008
SUZUKI, J. BIOL. CHEM., vol. 281, 2006, pages 36944 - 36951
DEBOER ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 80, 1983, pages 21 - 25
WU ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 75, 1978, pages 5442 - 5446
FURUSAKI, ISR. J. CHEM., vol. 10, 1972, pages 173 - 187
NOGUCHI, NAT. CHEM. BIOL., vol. 6, 2010, pages 641 - 643
NOGUCHI, AKIO ET AL.: "A copper-containing oxidase catalyzes C-nitrosation in nitrosobenzamide biosynthesis", NAT. CHEM. BIOL., vol. 6, 2010, pages 641 - 643, XP055154720
SIKORA, ALISON L. ET AL.: "Kinetic and chemical mechanism of arylamine N-acetyltransferase from Mycobacterium tuberculosis", BIOCHEMISTRY, vol. 47, 2008, pages 10781 - 10789, XP055154723
DATABASE GENBANK [online] 30 November 2006 (2006-11-30), XP003033756, Database accession no. AB259663.1
DATABASE GENBANK [online] 25 May 2010 (2010-05-25), XP003033757, Database accession no. AB530136.1
See also references of EP 2821479A4
J. BIOL. CHEM., vol. 281, 2006, pages 36944 - 36951
J. BACTERIOL., vol. 189, 2007, pages 2155 - 2159
BIOCHIM. BIOPHYS. ACTA, vol. 1475, 2000, pages 10 - 16
J. ANTIBIOT., vol. 59, 2006, pages 464
J. BIOL. CHEM., vol. 272, no. 13, 1997, pages 8611 - 7
PROC. NATL. ACAD. SCI. USA., vol. 97, no. 12, 6 June 2000 (2000-06-06), pages 6640 - 5
KARLIN; ALTSCHUL, PRO. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873
PEARSON, METHODS ENZYMOL., vol. 183, 1990, pages 63
JOURNAL OF BIOCHEMISTRY, vol. 281, no. 48, pages 36944 - 36951
CADWELL, R. C, PCR METH. APPL., vol. 2, 1992, pages 28
STEMMER, W. P., NATURE, vol. 370, 1994, pages 389
ZHAO, H., NATURE BIOTECHNOL., vol. 16, 1998, pages 258
SUZUKI ET AL., J. BIO. CHEM., vol. 281, 2006, pages 823 - 833
KIKUCHI ET AL., FEMS MICROBIOLOGY LETTERS, vol. 173, 1999, pages 211 - 215
FALCO ET AL., BIOTECHNOLOGY, vol. 13, 1995, pages 577 - 582
GENE, vol. 39, 1985, pages 281 - 286
BIO/TECHNOLOGY, vol. 7, 1989, pages 1067 - 1070
KRICHELDORF, MAKROMOL. CHEM., vol. 193, 1992, pages 2467 - 2476
MARCOS-FERNANDEZ, POLYMER, vol. 42, 2001, pages 7933 - 7941
SUZUKI, J. BACTERIOL., vol. 189, 2007, pages 2155 - 2159
KESELER ET AL., NUCLEIC ACIDS RES., vol. 33, 2005, pages 334 - 337, Retrieved from the Internet
HALDIMANN, J. BACTERIOL., vol. 183, 2001, pages 6384 - 6393
BABA, MOL. SYST. BIOL., vol. 2, 2006, pages 2006 - 2008
SUZUKI, J. BIOL. CHEM., vol. 281, 2006, pages 36944 - 36951
DEBOER ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 80, 1983, pages 21 - 25
WU ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 75, 1978, pages 5442 - 5446
FURUSAKI, ISR. J. CHEM., vol. 10, 1972, pages 173 - 187
NOGUCHI, NAT. CHEM. BIOL., vol. 6, 2010, pages 641 - 643
Attorney, Agent or Firm:
SAKAI, Hiroaki et al. (JP)
Hiroaki Sakai (JP)
Hiroaki Sakai (JP)
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