Title:
ESTABLISHMENT OF THERAPY AND DIAGNOSIS FOR ALLERGIC DISEASES THROUGH CONTROL OF IMMUNOGLOBULIN-BINDING PROTEIN
Document Type and Number:
WIPO Patent Application WO/2023/100977
Kind Code:
A1
Abstract:
The present invention addresses the problem of revealing a symptom onset mechanism of allergies in which bacteria belonging to the family Lachnospiraceae including Ruminococcus gnavus (R. gnavus) which is an enteric bacterium is involved, and developing a means for preventing or treating allergies by intervening in the mechanism. As a result of conducting thorough investigation, the present inventors have found that Ibp protein from bacteria belonging to the family Lachnospiraceae is involved in the onset of allergies, and have shown that said problem can be solved. Specifically, it is possible to prevent allergic reactions occurring in a body by administering, to the body, or inducing production of, within the body, a substance that binds to Ibp protein from bacteria belonging to the family Lachnospiraceae.
Inventors:
FUKUDA SHINJI (JP)
NAKATO GAKU (JP)
OBANA NOZOMU (JP)
FURUKAWA RISAKO (JP)
NAKATO GAKU (JP)
OBANA NOZOMU (JP)
FURUKAWA RISAKO (JP)
Application Number:
PCT/JP2022/044364
Publication Date:
June 08, 2023
Filing Date:
December 01, 2022
Export Citation:
Assignee:
KANAGAWA INSTITUTE OF INDUSTRIAL SCIENCE AND TECH (JP)
UNIV TSUKUBA (JP)
METAGEN INC (JP)
UNIV TSUKUBA (JP)
METAGEN INC (JP)
International Classes:
A61K45/00; A61K39/02; A61K39/395; A61P37/08; C12Q1/02; G01N33/68; C07K14/195
Foreign References:
| CN112442533A | 2021-03-05 | |||
| KR102134534B1 | 2020-07-16 | |||
| JP2021512106A | 2021-05-13 | |||
| JP2015500792A | 2015-01-08 |
Other References:
SHIOTANI AKIKO, RYO KATSUMATA, SHINYA FUKUSHIMA, YUKIKO HANDA, KYOSUKE GODA, MOTOYASU OOSAWA, TAKAHISA MURAO, OSAMU HANDA, HIROSHI: "MUCOSA-ASSOCIATED INTESTINAL MICOBIOTA AND SERUM CYTOKINES IN PATIENTS WITH DIARRHEA PREDOMINANT IRRITABE BOWEL SYNDROME AND IGE MEDIATED HYPERSENSITIVITY", GASTROENTEROLOGY (AGA ABSTRACTS), vol. 158, no. 6, supp.1, 1 May 2020 (2020-05-01), pages S900 - S901, XP093070057
BOROWSKA MARTA T., DREES CHRISTOPH, YARAWSKY ALEXANDER E., VISWANATHAN MAYURI, RYAN SEAN M., BUNKER JEFFREY J., HERR ANDREW B., BE: "The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 118, no. 39, 28 September 2021 (2021-09-28), XP093070063, ISSN: 0027-8424, DOI: 10.1073/pnas.2023898118
BOROWSKA MARTA T., DREES CHRISTOPH, YARAWSKY ALEXANDER E., VISWANATHAN MAYURI, RYAN SEAN M., BUNKER JEFFREY J., HERR ANDREW B., BE: "The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 118, no. 39, 28 September 2021 (2021-09-28), XP093070063, ISSN: 0027-8424, DOI: 10.1073/pnas.2023898118
Attorney, Agent or Firm:
UCHIYAMA Tsutomu et al. (JP)
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