Title:
ESTERS OF L-CARNITINE OR ALKANOYL L-CARNITINES
Document Type and Number:
WIPO Patent Application WO2000061543
Kind Code:
A3
Abstract:
Esters of L-carnitine and alkanoyl L-carnitines are described which can be used as cationic lipids for the intracellular delivery of pharmacologically active compounds. New esters of L-carnitine and alkanoyl L-carnitines of formula (I) are also disclosed wherein the R groups are as defined in the description.
Inventors:
PISANO CLAUDIO (IT)
TINTI MARIA ORNELLA (IT)
SANTANIELLO MOSE (IT)
CRITELLI LUCIANA (IT)
SALVATORI GIOVANNI (IT)
TINTI MARIA ORNELLA (IT)
SANTANIELLO MOSE (IT)
CRITELLI LUCIANA (IT)
SALVATORI GIOVANNI (IT)
Application Number:
PCT/IT2000/000137
Publication Date:
January 11, 2001
Filing Date:
April 11, 2000
Export Citation:
Assignee:
SIGMA TAU IND FARMACEUTI (IT)
PISANO CLAUDIO (IT)
TINTI MARIA ORNELLA (IT)
SANTANIELLO MOSE (IT)
CRITELLI LUCIANA (IT)
SALVATORI GIOVANNI (IT)
PISANO CLAUDIO (IT)
TINTI MARIA ORNELLA (IT)
SANTANIELLO MOSE (IT)
CRITELLI LUCIANA (IT)
SALVATORI GIOVANNI (IT)
International Classes:
A61K8/00; A61K8/11; A61K8/14; A61K8/30; A61K8/37; A61K8/44; A61K9/127; A61K31/225; A61K31/337; A61K31/4745; A61K39/00; A61K45/00; A61K47/18; A61K47/24; A61K47/44; A61K48/00; A61P35/00; A61Q19/00; C07C229/02; C07C229/22; C07C229/00; (IPC1-7): C07C229/22; A61K7/00; A61K9/127
Domestic Patent References:
| WO1996039193A2 | 1996-12-12 | |||
| WO1999057094A2 | 1999-11-11 |
Other References:
WANG, JINKANG ET AL: "Synthesis and Characterization of Long Chain Alkyl Acyl Carnitine Esters. Potentially Biodegradable Cationic Lipids for Use in Gene Delivery", J. MED. CHEM. (1998), 41(13), 2207-2215, XP000915230
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