Title:
ESTRA-1,3,5(10)-TRIENE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2001/081364
Kind Code:
A1
Abstract:
Steroid sulfatase inhibitors containing as the active ingredient estra-1,3,5(10)-triene derivatives represented by the following general formula (I) or pharmacologically acceptable salts thereof: (I) wherein R?1¿ and R?2¿ are the same or different and each represents hydrogen, lower alkyl, etc.; R?3¿ represents hydrogen, etc.; R?4¿ represents hydrogen, etc.; R?5¿ represents hydrogen, etc.; and R?6¿ represents cyano, amino, COR?53¿ (wherein R?53¿ represents substituted lower alkyl, etc.), optionally substituted aryl, an optionally substituted heterocycle, etc.
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Inventors:
INO YOJI (JP)
AMISHIRO NOBUYOSHI (JP)
MIYATA MAYUMI (JP)
AGATSUMA TSUTOMU (JP)
HAYASHI KOZUE (JP)
TAKAHASHI TAKESHI (JP)
AKINAGA SHIRO (JP)
MURAKATA CHIKARA (JP)
AMISHIRO NOBUYOSHI (JP)
MIYATA MAYUMI (JP)
AGATSUMA TSUTOMU (JP)
HAYASHI KOZUE (JP)
TAKAHASHI TAKESHI (JP)
AKINAGA SHIRO (JP)
MURAKATA CHIKARA (JP)
Application Number:
PCT/JP2001/003505
Publication Date:
November 01, 2001
Filing Date:
April 24, 2001
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK (JP)
INO YOJI (JP)
AMISHIRO NOBUYOSHI (JP)
MIYATA MAYUMI (JP)
AGATSUMA TSUTOMU (JP)
HAYASHI KOZUE (JP)
TAKAHASHI TAKESHI (JP)
AKINAGA SHIRO (JP)
MURAKATA CHIKARA (JP)
INO YOJI (JP)
AMISHIRO NOBUYOSHI (JP)
MIYATA MAYUMI (JP)
AGATSUMA TSUTOMU (JP)
HAYASHI KOZUE (JP)
TAKAHASHI TAKESHI (JP)
AKINAGA SHIRO (JP)
MURAKATA CHIKARA (JP)
International Classes:
A61P5/24; A61P5/32; A61P13/08; A61P15/00; A61P35/00; A61P43/00; C07J41/00; C07J43/00; (IPC1-7): C07J41/00; C07J43/00; A61K31/56; A61K31/58; A61P43/00; A61P5/24; A61P5/32; A61P35/00; A61P13/08; A61P15/00
Domestic Patent References:
| WO2000043408A2 | 2000-07-27 | |||
| WO1998032763A1 | 1998-07-30 | |||
| WO1999003876A1 | 1999-01-28 | |||
| WO1999033858A2 | 1999-07-08 |
Other References:
See also references of EP 1284272A4
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