Title:
ESTROGEN RECEPTOR MODULATORS
Document Type and Number:
WIPO Patent Application WO2002032377
Kind Code:
A3
Abstract:
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restinosis, gynacomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.
Inventors:
DININNO FRANK P (US)
CHEN HELEN Y (US)
KIM SEONGKON (US)
WU JANE Y (US)
CHEN HELEN Y (US)
KIM SEONGKON (US)
WU JANE Y (US)
Application Number:
PCT/US2001/042735
Publication Date:
August 22, 2002
Filing Date:
October 15, 2001
Export Citation:
Assignee:
MERCK & CO INC (US)
DININNO FRANK P (US)
CHEN HELEN Y (US)
KIM SEONGKON (US)
WU JANE Y (US)
DININNO FRANK P (US)
CHEN HELEN Y (US)
KIM SEONGKON (US)
WU JANE Y (US)
International Classes:
A61K31/395; A61K31/397; A61K31/40; A61K31/4025; A61K31/445; A61K31/4535; A61K31/55; A61P3/04; A61P3/06; A61P5/00; A61P5/30; A61P5/32; A61P9/00; A61P9/10; A61P15/00; A61P19/00; A61P19/10; A61P25/28; A61P35/00; A61P35/04; C07D205/00; C07D213/02; C07D327/06; C07D339/08; C07D405/00; C07D409/00; C07D411/00; C07D411/04; C07D411/12; (IPC1-7): A61K31/395; A61K31/55; A61K31/445; A61K31/40; A61P5/00; C07D405/00; C07D409/00; C07D205/00; C07D213/02; C07D411/00
Other References:
BENDINSKAS ET AL.: "Sequence-specific photomodification of DNA by an oligonucleotide-phenanthrodihydrodioxin conjugate", BIOCONJUGATE CHEMISTRY, vol. 9, no. 5, September 1998 (1998-09-01), pages 555 - 563, XP002909731
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