Title:
ETHER COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES
Document Type and Number:
WIPO Patent Application WO2002030863
Kind Code:
A3
Abstract:
The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
Inventors:
DASSEUX JEAN-LOUIS H
ONICIU CARMEN DANIELA
ONICIU CARMEN DANIELA
Application Number:
PCT/US2001/031873
Publication Date:
July 31, 2003
Filing Date:
October 11, 2001
Export Citation:
Assignee:
ESPERION THERAPEUTICS INC (US)
International Classes:
A61K31/08; A61K31/19; A61K31/275; A61P3/04; A61P3/06; A61P7/02; A61P9/00; A61P9/12; A61P13/12; A61P1/18; A61P15/10; A61P25/28; A61P29/00; A61P31/00; A61P31/04; A61P35/00; C07C43/13; C07C43/178; C07C43/295; C07C47/198; C07C47/277; C07C59/305; C07C59/60; C07C59/64; C07C59/66; C07C59/68; C07C69/708; C07C69/712; C07C261/04; C07C309/10; C07D233/74; C07D233/84; C07D257/04; C07D261/08; C07D261/12; C07D305/12; C07D307/12; C07D307/33; C07D307/42; C07D309/06; C07D309/30; C07D309/32; C07D309/38; C07D309/40; C07D519/00; C07F9/09; C07F9/24; C07F9/44; (IPC1-7): C07C59/305; A61K31/19; A61K31/075; A61K31/35; A61P9/00; C07C59/68; C07C43/13; C07C43/295; C07D309/32
Foreign References:
| EP0032063A2 | 1981-07-15 | |||
| US5648387A | 1997-07-15 | |||
| US4794113A | 1988-12-27 |
Other References:
C. BRAUNWEILER: "Synthesis and Properties of 7,7,12,12,tetramethyl-1,4-dioxacyclotetradecane-8,9,10,11-tetrone", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, no. 6, 1999, Weinheim, pages 1303 - 1310, XP002233884
B. P. CZECH: "Functionalized 13-Crown-4, 14-Crown-4, 15-Crown-4, and 16-Crown-4 Compounds: Synthesis and Lithium Ion Complexation", JOURNAL OF ORGANIC CHEMISTRY, vol. 49, no. 25, 1984, EASTON US, pages 4805 - 4810, XP002233885
B. P. CZECH: "Functionalized 13-Crown-4, 14-Crown-4, 15-Crown-4, and 16-Crown-4 Compounds: Synthesis and Lithium Ion Complexation", JOURNAL OF ORGANIC CHEMISTRY, vol. 49, no. 25, 1984, EASTON US, pages 4805 - 4810, XP002233885
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