Title:
ETHER DERIVATIVES HAVING NEURONAL ACTIVITY
Document Type and Number:
WIPO Patent Application WO2000046193
Kind Code:
A3
Abstract:
The invention relates to the compounds of Formula (I), as well as the process for their production and their use as pharmaceutical agents. The invention also relates to the compounds of Formula (IA), their isomers and physiologically compatible salts.
Inventors:
BRUMBY THOMAS
MCDONALD FIONA
OTTOW ECKHARD
SCHNEIDER HERBERT
MCDONALD FIONA
OTTOW ECKHARD
SCHNEIDER HERBERT
Application Number:
PCT/US2000/002773
Publication Date:
December 21, 2000
Filing Date:
February 03, 2000
Export Citation:
Assignee:
SCHERING AG (DE)
VERTEX PHARMA (US)
VERTEX PHARMA (US)
International Classes:
C07D207/08
Domestic Patent References:
| WO1997046554A1 | 1997-12-11 | |||
| WO1996040682A1 | 1996-12-19 | |||
| WO1999032480A1 | 1999-07-01 | |||
| WO1999065451A2 | 1999-12-23 | |||
| WO1996041609A2 | 1996-12-27 | |||
| WO1999062881A1 | 1999-12-09 |
Foreign References:
| EP0229630A2 | 1987-07-22 | |||
| US5721256A | 1998-02-24 |
Other References:
FUJISAWA, TAMOTSU ET AL: "Stereocontrolled addition reaction of organometallics to chiral.alpha.-keto amides", BULL. CHEM. SOC. JPN. (1990), 63(7), 1894-7, XP000916071
KOFT, EMIL R. ET AL: "The formation and alkylation of.alpha.-keto amide dianions", TETRAHEDRON LETT. (1986), 27(20), 2227-30, XP000916202
BYUN, IL SUK ET AL: "Highly diastereoselective reduction of new chiral.alpha.-keto amides", SYNTH. COMMUN. (1995), 25(13), 1963-9, XP000916268
OKAMOTO, YOSHIO ET AL: "Asymmetric polymerization of aromatic isocyanates with optically active anionic initiators", J. POLYM. SCI., PART A: POLYM. CHEM. (1994), 32(2), 309-15, XP000424261
TSUGE H ET AL: "Highly Diastereoselective Michael Addition to Optically Active Trifluoromethylated alpha,beta-Unsaturated Sulfonamides Based on Their Hinge-Like Conformation", TETRAHEDRON,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 53, no. 3, 20 January 1997 (1997-01-20), pages 823 - 838, XP004105184, ISSN: 0040-4020
IBUKA, TOSHIRO ET AL: "Aza-Payne Rearrangement of Activated 2-Aziridinemethanols and 2,3-Epoxy Amines under Basic Conditions", J. ORG. CHEM. (1995), 60(7), 2044-58, 1995, XP000916214
CHOJI KASHIMA ET AL.: "Lithium Aluminium Hydride Reduction of Chiral Benzoylformamides Derivwd from Chiral Amino Alcohols", J. CHEM. PERKINS TRANS I, 1987, pages 1495 - 15000, XP000916103
VAN DEN BROEK, LEON A. G. M. ET AL: "Asymmetric Diels-Alder reactions with sulfines derived from proline", J. ORG. CHEM. (1984), 49(10), 1691-5, 1984, XP000916217
NKUNYA, M. H. H. ET AL: "Asymmetric synthesis of.alpha.,.beta.-epoxy sulfonamides (oxiranesulfonamides)", RECL. TRAV. CHIM. PAYS-BAS (1985), 104(10), 253-9, 1985, XP000916218
THOMAS R M ET AL: "An efficient and selective deprotection of allyl ethers by a CeCl3.7H2O- NaI system", TETRAHEDRON LETTERS,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 40, no. 40, 1 October 1999 (1999-10-01), pages 7293 - 7294, XP004179039, ISSN: 0040-4039
HAMILTON G S: "IMMUNOPHILIN LIGANDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS", EXPERT OPINION ON THERAPEUTIC PATENTS,GB,ASHLEY PUBLICATIONS, vol. 8, no. 9, 1998, pages 1109 - 1124, XP000852684, ISSN: 1354-3776
KOFT, EMIL R. ET AL: "The formation and alkylation of.alpha.-keto amide dianions", TETRAHEDRON LETT. (1986), 27(20), 2227-30, XP000916202
BYUN, IL SUK ET AL: "Highly diastereoselective reduction of new chiral.alpha.-keto amides", SYNTH. COMMUN. (1995), 25(13), 1963-9, XP000916268
OKAMOTO, YOSHIO ET AL: "Asymmetric polymerization of aromatic isocyanates with optically active anionic initiators", J. POLYM. SCI., PART A: POLYM. CHEM. (1994), 32(2), 309-15, XP000424261
TSUGE H ET AL: "Highly Diastereoselective Michael Addition to Optically Active Trifluoromethylated alpha,beta-Unsaturated Sulfonamides Based on Their Hinge-Like Conformation", TETRAHEDRON,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 53, no. 3, 20 January 1997 (1997-01-20), pages 823 - 838, XP004105184, ISSN: 0040-4020
IBUKA, TOSHIRO ET AL: "Aza-Payne Rearrangement of Activated 2-Aziridinemethanols and 2,3-Epoxy Amines under Basic Conditions", J. ORG. CHEM. (1995), 60(7), 2044-58, 1995, XP000916214
CHOJI KASHIMA ET AL.: "Lithium Aluminium Hydride Reduction of Chiral Benzoylformamides Derivwd from Chiral Amino Alcohols", J. CHEM. PERKINS TRANS I, 1987, pages 1495 - 15000, XP000916103
VAN DEN BROEK, LEON A. G. M. ET AL: "Asymmetric Diels-Alder reactions with sulfines derived from proline", J. ORG. CHEM. (1984), 49(10), 1691-5, 1984, XP000916217
NKUNYA, M. H. H. ET AL: "Asymmetric synthesis of.alpha.,.beta.-epoxy sulfonamides (oxiranesulfonamides)", RECL. TRAV. CHIM. PAYS-BAS (1985), 104(10), 253-9, 1985, XP000916218
THOMAS R M ET AL: "An efficient and selective deprotection of allyl ethers by a CeCl3.7H2O- NaI system", TETRAHEDRON LETTERS,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 40, no. 40, 1 October 1999 (1999-10-01), pages 7293 - 7294, XP004179039, ISSN: 0040-4039
HAMILTON G S: "IMMUNOPHILIN LIGANDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS", EXPERT OPINION ON THERAPEUTIC PATENTS,GB,ASHLEY PUBLICATIONS, vol. 8, no. 9, 1998, pages 1109 - 1124, XP000852684, ISSN: 1354-3776
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