Title:
ETHINYL-PYRAZOLE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2012/015024
Kind Code:
A1
Abstract:
Provided is a novel compound represented by formula [I] or a pharmaceutically acceptable salt thereof having antagonistic activity against group II metabolism-type glutamic acid (m-Glu) receptors. The compound or pharmaceutically acceptable salt thereof is useful as a prophylactic or therapeutic agent for diseases such as new mood disorders (depressive and bipolar disorders), anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic stress disorder, specific phobias, and acute stress disorder), schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, drug dependence, convulsions, tremors, pain, sleep disorders, and the like.
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Inventors:
NAKAMURA TOSHIO (JP)
SAKAGAMI KAZUNARI (JP)
KONISHI KAZUHIDE (JP)
YAMAMOTO KANAKO (JP)
MASUDA SEIJI (JP)
MATSUDA YOHEI (JP)
OKADA KUMIKO (JP)
SHIBATA TSUYOSHI (JP)
OHTA HIROSHI (JP)
YASUHARA AKITO (JP)
KAWAMOTO HIROSHI (JP)
SAKAGAMI KAZUNARI (JP)
KONISHI KAZUHIDE (JP)
YAMAMOTO KANAKO (JP)
MASUDA SEIJI (JP)
MATSUDA YOHEI (JP)
OKADA KUMIKO (JP)
SHIBATA TSUYOSHI (JP)
OHTA HIROSHI (JP)
YASUHARA AKITO (JP)
KAWAMOTO HIROSHI (JP)
Application Number:
PCT/JP2011/067394
Publication Date:
February 02, 2012
Filing Date:
July 29, 2011
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
NAKAMURA TOSHIO (JP)
SAKAGAMI KAZUNARI (JP)
KONISHI KAZUHIDE (JP)
YAMAMOTO KANAKO (JP)
MASUDA SEIJI (JP)
MATSUDA YOHEI (JP)
OKADA KUMIKO (JP)
SHIBATA TSUYOSHI (JP)
OHTA HIROSHI (JP)
YASUHARA AKITO (JP)
KAWAMOTO HIROSHI (JP)
NAKAMURA TOSHIO (JP)
SAKAGAMI KAZUNARI (JP)
KONISHI KAZUHIDE (JP)
YAMAMOTO KANAKO (JP)
MASUDA SEIJI (JP)
MATSUDA YOHEI (JP)
OKADA KUMIKO (JP)
SHIBATA TSUYOSHI (JP)
OHTA HIROSHI (JP)
YASUHARA AKITO (JP)
KAWAMOTO HIROSHI (JP)
International Classes:
C07D231/12; A61K31/415; A61K31/4155; A61K31/417; A61K31/4174; A61K31/42; A61K31/4245; A61K31/4439; A61K31/4709; A61K31/496; A61K31/506; A61P25/04; A61P25/08; A61P25/18; A61P25/20; A61P25/22; A61P25/28; A61P25/30; A61P43/00; C07D231/14; C07D231/38; C07D401/04; C07D401/06; C07D401/10; C07D401/12; C07D403/04; C07D403/06; C07D413/04
Domestic Patent References:
| WO2009024491A1 | 2009-02-26 | |||
| WO2002046166A1 | 2002-06-13 | |||
| WO2010063487A1 | 2010-06-10 | |||
| WO2005123703A2 | 2005-12-29 | |||
| WO2001029011A2 | 2001-04-26 | |||
| WO2001029012A2 | 2001-04-26 | |||
| WO2006099972A1 | 2006-09-28 |
Other References:
BIOCHEMICAL PHARMACOLOGY, vol. 75, 2008, pages 997 - 1006
NEUROPHARMACOLOGY, vol. 46, 2004, pages 907 - 917
"Comprehensive Organic Transformations", 1999, JOHN WILEY & SONS, INC.
"Comprehensive Organic Transformations", 1999, JOHN WILEY & SONS, INC
"Protective Groups in Organic Synthesis", JOHN WILEY & SONS, INC.
SYNLETT, vol. 15, 2003, pages 2428 - 2439
CHEM. REV., vol. 109, 2009, pages 2551 - 2651
SYNLETT, 1996, pages 521 - 522
SYNTHESIS, 2000, pages 185 - 213
"Protective Groups in Organic Synthesis", JOHN WILEY & SONS, INC
See also references of EP 2599775A4
NEUROPHARMACOLOGY, vol. 46, 2004, pages 907 - 917
"Comprehensive Organic Transformations", 1999, JOHN WILEY & SONS, INC.
"Comprehensive Organic Transformations", 1999, JOHN WILEY & SONS, INC
"Protective Groups in Organic Synthesis", JOHN WILEY & SONS, INC.
SYNLETT, vol. 15, 2003, pages 2428 - 2439
CHEM. REV., vol. 109, 2009, pages 2551 - 2651
SYNLETT, 1996, pages 521 - 522
SYNTHESIS, 2000, pages 185 - 213
"Protective Groups in Organic Synthesis", JOHN WILEY & SONS, INC
See also references of EP 2599775A4
Attorney, Agent or Firm:
ASAMURA Kiyoshi et al. (JP)
浅村 皓 (JP)
浅村 皓 (JP)
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