Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
ETHYLENEDICYSTEINE (EC)-DRUG CONJUGATES, COMPOSITIONS AND METHODS FOR TISSUE SPECIFIC DISEASE IMAGING
Document Type and Number:
WIPO Patent Application WO2004044227
Kind Code:
A3
Abstract:
The invention provides, in a general sense, a new labeling strategy employing compounds that are are N2S2 chelates conjugated to a targeting ligand, wherein the targeting ligand is a disease cell cycle targeting compound, a tumor angiogenesis targeting ligand, a tumor apoptosis targeting ligand, a disease receptor targeting ligand, amifostine, angiostatin, monoclonal antibody C225, monoclonal antibody CD31, monoclonal antibody CD40, capecitabine, COX-2, deoxycytidine, fullerene, herceptin, human serum albumin, lactose, leuteinizing hormone, pyridoxal, quinazoline, thalidomide, transferrin, or trimethyl lysine. The present invention also pertains to kits employing the compounds of interest, and methods of assessing the pharmacology of an agent of interest using the present compounds.

Inventors:
YANG DAVID J (US)
YU DONG-FANG (US)
OH CHANG-SOK (US)
BRYANT JERRY L JR (US)
Application Number:
PCT/US2003/036078
Publication Date:
November 11, 2004
Filing Date:
November 07, 2003
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
UNIV TEXAS (US)
CELL POINT LLC (US)
YANG DAVID J (US)
YU DONG-FANG (US)
OH CHANG-SOK (US)
BRYANT JERRY L JR (US)
International Classes:
A61K49/00; A61K51/00; A61K51/08; A61K51/10; A61M36/14; C07F5/00; C07F13/00; C07K16/46; A61K; C12Q; (IPC1-7): A61K51/00; A61M36/14
Domestic Patent References:
WO2001091807A22001-12-06
Other References:
ZARENEYRIZI ET AL: "Synthesis of [99mTc]ethylenedicysteine-colchicine for evaluation of antiangiogenic effect", ANTICANCER DRUGS, vol. 10, no. 7, 1999, pages 685 - 692, XP002904378
Download PDF: