ETOPOSIDE ANALOGS AND METHODS OF USE THEREOF

Title:

ETOPOSIDE ANALOGS AND METHODS OF USE THEREOF

Document Type and Number:

WIPO Patent Application WO2004000859

Kind Code:

A3

Abstract:

Etoposide analogs such as 4'-O-demethyl-4beta-[4''-(methyl-L-tyrosine-N-carbonyl)-anilino]-4-desoxy-podophyllotoxin (12) and 4'-O-demethyl-4beta-[4''-(methyl-L-tryptophan-N-carbonyl)-anilino]-4-desoxypodophyllotoxin (13) are described, along with pharmaceutical formulations containing the same, methods of use thereof, and intermediates and methods of making the same.

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Inventors:

LEE KUO-HSIUNG (US)
XIAO ZHIYAN (US)
BASTOW KENNETH F (US)

Application Number:

PCT/US2003/019629

Publication Date:

September 23, 2004

Filing Date:

June 20, 2003

Export Citation:

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Assignee:

UNIV NORTH CAROLINA (US)
LEE KUO-HSIUNG (US)
XIAO ZHIYAN (US)
BASTOW KENNETH F (US)

International Classes:

C07D493/04; C07D497/04; (IPC1-7): C07D317/70; C07D407/00; C07D233/02; C07D405/00; C07D307/77; A61K31/415; A61K31/40; A61K31/38; A61K31/335

Foreign References:

US5332811A

1994-07-26

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