EUTECTIC OF TELMISARTAN AND HYDROCHLOROTHIAZIDE - SHANGHAI INST MATERIA MEDICA CAS

Title:

EUTECTIC OF TELMISARTAN AND HYDROCHLOROTHIAZIDE

Document Type and Number:

WIPO Patent Application WO/2019/033969

Kind Code:

A1

Abstract:

Disclosed are a eutectic of telmisartan and hydrochlorothiazide, a preparation method therefor and the use thereof. In the eutectic, the molar ratio of telmisartan to hydrochlorothiazide is 1:1. The eutectic of telmisartan and hydrochlorothiazide is fully characterized by X-ray single crystal diffraction analysis, H nuclear magnetic resonance spectroscopy, thermogravimetric analysis, differential scanning calorimetry, infrared spectrum analysis and other means, and it is found that the maximum blood concentration of the eutectic in SD rats is higher than that of both hydrochlorothiazide and telmisartan. The eutectic of telmisartan and hydrochlorothiazide has a simple preparation method and good physical and chemical properties.

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Inventors:

MEI XUEFENG (CN)
WANG JIANRONG (CN)
YU QIHUI (CN)

Application Number:

PCT/CN2018/099349

Publication Date:

February 21, 2019

Filing Date:

August 08, 2018

Export Citation:

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Assignee:

SHANGHAI INST MATERIA MEDICA CAS (CN)

International Classes:

A61K31/4184; C07D235/18; A61K31/549; A61P9/00; A61P9/04; A61P9/12; C07D285/28; C07D285/32

Domestic Patent References:

WO2011025467A1	2011-03-03
WO2011147026A2	2011-12-01

Foreign References:

CN107501192A	2017-12-22
CN1780618A	2006-05-31
CN102512423A	2012-06-27
CN101080225A	2007-11-28
CN106562973A	2017-04-19

Attorney, Agent or Firm:

KINGSOUND & PARTNERS (CN)

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