EVALUATING METHOD, CALCULATING METHOD, EVALUATING DEVICE, CALCULATING DEVICE, EVALUATING PROGRAM, CALCULATING PROGRAM, STORAGE MEDIUM, EVALUATING SYSTEM, AND TERMINAL DEVICE OF AMYLOID BETA ACCUMULATION IN BRAIN

Title:

Document Type and Number:

WIPO Patent Application WO/2020/203878

Kind Code:

A1

Abstract:

The present invention addresses the problem of providing an evaluating method, etc. which can provide highly reliable information which can serve as a reference in knowing the amyloid beta accumulation state in the brain. In the present embodiment, the Aβ accumulation state in the brain is evaluated with respect to a subject to be evaluated by using at least one measurement value from among Ala, Arg, Asn, Cit, Cys2, EtOHNH2, Gln, Glu, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Tau, Thr, Trp, Tyr, Val, 1-MeHis, 3-hKyn, 3-MeHis, aABA, aAiBA, ADMA, Allyl-Cys, aAAA, bAiBA, GABA, hArg, hCit, Hypotaurine, HyPro, Kyn, Cystathionine, MeCys, N6-AcLys, N8-AcSpd, PEA, Pipecolic-acid, Put, Sar, SDMA, Spd, Thioproline, and BCAA in the blood of the subject to be evaluated.

Inventors:

YANO YUKI (JP)
ARASHIDA NAOKO (JP)
SATO WATARU (JP)
HIBI SHIGEKI (JP)
MIYAGAWA TAKEHIKO (JP)
KOBAYASHI KIYOAKI (JP)

Application Number:

PCT/JP2020/014303

Publication Date:

October 08, 2020

Filing Date:

March 27, 2020

Export Citation:

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Assignee:

AJINOMOTO KK (JP)
EISAI R&D MAN CO LTD (JP)

International Classes:

C07K14/47; G01N33/48; G01N33/68

Domestic Patent References:

WO2015178398A1	2015-11-26
WO2018008764A1	2018-01-11
WO2018008763A1	2018-01-11

Foreign References:

JP2018515765A

2018-06-14

Other References:

BURNHAM, S. ET AL.: "A blood-based predictor for neocortical Abeta burden in Alzheimer's disease: results from the AIBL study", MOLECULAR PSYCHIATRY, vol. 19, 30 April 2013 (2013-04-30), pages 519 - 526, XP055745443
ALKALAY, A. ET AL.: "Plasma acetylcholinesterase activity correlates with intracerebral beta-amyloid load", CURR ALZHEIMER RES., vol. 10, no. 1, January 2013 (2013-01-01), pages 48 - 56, XP055745445