Title:
EVALUATION OF ADENOCARCINOMA OF THE PROSTATE AND BREAST USING ANTI-DYSTROGLYCAN ANTIBODIES
Document Type and Number:
WIPO Patent Application WO2001001151
Kind Code:
A3
Abstract:
Disclosed is a method for diagnosing the tumorigenic grade of a malignant tissue, especially human adenoarcinoma, for detecting a cancerous disease state in a tissue of a patient, or for identifying an individual at risk for the development of cancer. The method entails determining the amount of dystroglycan protein or mRNA of the malignant tissue relative to a standard. Similarly, a method for indentifying individuals at risk for developing cancer by screening for mutations in the dystroglycan gene, e.g. allelic loss of human chromosome 3p21.
Inventors:
CAMPBELL KEVIN P
HENRY MICHAEL
COHEN MICHAEL B
HENRY MICHAEL
COHEN MICHAEL B
Application Number:
PCT/US2000/040206
Publication Date:
April 26, 2001
Filing Date:
June 15, 2000
Export Citation:
Assignee:
UNIV IOWA RES FOUND (US)
International Classes:
G01N33/574; (IPC1-7): G01N33/68; G01N33/574
Foreign References:
| US5686073A | 1997-11-11 |
Other References:
HENRY M.D. ET AL.: "Reduced expression of dystroglycan in prostate and breast cancer", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 65, October 1999 (1999-10-01), pages A130, XP000974376
LOSASSO C. ET AL.: "Anomalous dystroglycan in carcinoma cell lines", FEBS LETTERS, vol. 484, 10 November 2000 (2000-11-10), pages 194 - 198, XP002155680
LOSASSO C. ET AL.: "Anomalous dystroglycan in carcinoma cell lines", FEBS LETTERS, vol. 484, 10 November 2000 (2000-11-10), pages 194 - 198, XP002155680
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