Title:
EVALUATION METHOD, CALCULATION METHOD, EVALUATION DEVICE, CALCULATION DEVICE, EVALUATION PROGRAM, CALCULATION PROGRAM, RECORDING MEDIUM, EVALUATION SYSTEM AND TERMINAL DEVICE FOR RELATIVE PHARMACOLOGICAL ACTION OF COMBINATION OF IMMUNE CHECKPOINT INHIBITOR WITH ANTICANCER DRUG AS CONCOMITANT DRUG COMPARED TO PHARMACOLOGICAL ACTION OF IMMUNE CHECKPOINT INHIBITOR ALONE
Document Type and Number:
WIPO Patent Application WO/2023/195447
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing an evaluation method, etc., capable of providing reliable information that can be used as a reference for understanding an individual difference in the expression of the relative pharmacological action of a combination of an immune checkpoint inhibitor with an anticancer drug, which is a concomitant agent, compared to the pharmacological action of the immune checkpoint inhibitor alone. The present embodiment evaluates the relative pharmacological action of a combination of an immune checkpoint inhibitor with an anticancer drug, which is a concomitant agent, in a subject to be evaluated, compared to the pharmacological action of the immune checkpoint inhibitor alone, by using the concentration of at least one metabolite selected from among Glu, Arg, Orn, Cit, His, Val, Phe, Tyr, Met, Pro, Asn, Leu, Lys, Thr, Ile, Gln, Ala, Ser, a-ABA, Trp, Gly, AnthA, hKyn, hTrp, Kyn, KynA, NP, QA and XA in the blood of the subject to be evaluated.
Inventors:
AZUMA KOICHI (JP)
MUROTANI KENTA (JP)
SASADA TETSURO (JP)
TAGAMI TOMOYUKI (JP)
HAGIWARA ASAMI (JP)
IMAIZUMI AKIRA (JP)
KARAKAWA SACHISE (JP)
KAWASAKI MIKA (JP)
MIYAGI YOHEI (JP)
TAMURA TOMOHIKO (JP)
SAITO HARUHIRO (JP)
NAKAHARA YOSHIRO (JP)
WEI FEIFEI (JP)
KASAJIMA RIKA (JP)
XIANG HUIHUI (JP)
BAN TATSUMA (JP)
MUROTANI KENTA (JP)
SASADA TETSURO (JP)
TAGAMI TOMOYUKI (JP)
HAGIWARA ASAMI (JP)
IMAIZUMI AKIRA (JP)
KARAKAWA SACHISE (JP)
KAWASAKI MIKA (JP)
MIYAGI YOHEI (JP)
TAMURA TOMOHIKO (JP)
SAITO HARUHIRO (JP)
NAKAHARA YOSHIRO (JP)
WEI FEIFEI (JP)
KASAJIMA RIKA (JP)
XIANG HUIHUI (JP)
BAN TATSUMA (JP)
Application Number:
PCT/JP2023/013821
Publication Date:
October 12, 2023
Filing Date:
April 03, 2023
Export Citation:
Assignee:
AJINOMOTO KK (JP)
KANAGAWA PREFECTURAL HOSPITAL ORGANIZATION (JP)
UNIV KURUME (JP)
PUBLIC UNIV CORP YOKOHAMA CITY UNIV (JP)
KANAGAWA PREFECTURAL HOSPITAL ORGANIZATION (JP)
UNIV KURUME (JP)
PUBLIC UNIV CORP YOKOHAMA CITY UNIV (JP)
International Classes:
G01N33/68
Domestic Patent References:
| WO2021090941A1 | 2021-05-14 | |||
| WO2020246336A1 | 2020-12-10 | |||
| WO2020171141A1 | 2020-08-27 |
Foreign References:
| US20190338370A1 | 2019-11-07 | |||
| JP2021012102A | 2021-02-04 |
Attorney, Agent or Firm:
SAKAI INTERNATIONAL PATENT OFFICE (JP)
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