Title:
EVOLUTION OF BIOACTIVE SEQUENCE-DEFINED SYNTHETIC POLYMERS USING DNA-TEMPLATED POLYMERIZATION
Document Type and Number:
WIPO Patent Application WO/2019/010441
Kind Code:
A8
Abstract:
The present invention provides methods and compositions for performing ordered multi- step syntheses involving modified nucleic acids by nucleic acid-mediated chemistry. This approach is useful for generating sequence-defined highly functionalized nucleic acid polymers. The invention also provides modified nucleic acid polymers that bind to proteins of interest (e.g., PCSK9 and IL-6), which are implicated in human disease.
Inventors:
LIU DAVID R (US)
CHEN ZHEN (US)
LICHTOR PHILLIP ANDREW (US)
CHEN ZHEN (US)
LICHTOR PHILLIP ANDREW (US)
Application Number:
PCT/US2018/041127
Publication Date:
January 31, 2019
Filing Date:
July 06, 2018
Export Citation:
Assignee:
HARVARD COLLEGE (US)
International Classes:
C12N15/10; C07H21/04; C12N15/67; C12P19/34
Attorney, Agent or Firm:
HEBERT, Alan M. (US)
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