Title:
EX-VIVO SELECTION OF T-CELLS WITH REDUCED ALLOREACTIVITY AND USE THEREOF IN BONE MARROW TRANSPLANTATIONS
Document Type and Number:
WIPO Patent Application WO2003012080
Kind Code:
A3
Abstract:
The invention relates to a reduction of allologous immune reactions. In said method the regulatory properties of antigen-presenting cells are used to eliminate ex-vivo graft vs host reactions.
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Inventors:
SHERIFF AHMED (DE)
Application Number:
PCT/EP2002/008052
Publication Date:
August 28, 2003
Filing Date:
July 19, 2002
Export Citation:
Assignee:
GENETHOR GMBH (DE)
SHERIFF AHMED (DE)
SHERIFF AHMED (DE)
International Classes:
A61K35/16; A61K35/26; C12N5/0784; A61K35/12; A61K39/00; (IPC1-7): C12N5/06; A61K35/12
Other References:
GUINAN EVA C ET AL: "Transplantation of anergic histoincompatible bone marrow allografts.", NEW ENGLAND JOURNAL OF MEDICINE, vol. 340, no. 22, 9 June 1999 (1999-06-09), pages 1704 - 1714, XP002187717, ISSN: 0028-4793
LU L ET AL: "ADENOVIRAL DELIVERY OF CTLA4LG INTO MYELOID DENDRITIC CELLS PROMOTES THEIR IN VITRO TOLEROGENICITY AND SURVIVAL IN ALLOGENEIC RECIPIENTS", GENE THERAPY, MACMILLAN PRESS LTD., BASINGSTOKE, GB, vol. 6, no. 4, 1999, pages 554 - 563, XP000946114, ISSN: 0969-7128
BLAZAR BRUCE R ET AL: "CD4+ T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand (CD40L:CD154) antibody lose their graft-versus-host disease lethality capacity but retain nominal antigen responses.", JOURNAL OF CLINICAL INVESTIGATION, vol. 102, no. 3, 1 August 1998 (1998-08-01), pages 473 - 482, XP002187718, ISSN: 0021-9738
ZELLER ET AL: "Induction of CD4+ T Cell Alloanitgen-Specific Hyporesponsiveness by Il-10 and TGF-beta", THE JOURNAL OF IMMUNOLOGY, vol. 163, 1999, pages 3684 - 3691, XP002187719
CHAMPLIN RICHARD ET AL: "Harnessing graft-versus-malignancy: Non-myeloablative preparative regimens for allogeneic haematopoietic transplantation, an evolving strategy for adoptive immunotherapy.", BRITISH JOURNAL OF HAEMATOLOGY, vol. 111, no. 1, October 2000 (2000-10-01), pages 18 - 29, XP002187720, ISSN: 0007-1048
APPLEMAN LEONARD J ET AL: "Helper T cell anergy: From biochemistry to cancer pathophysiology and therapeutics.", JOURNAL OF MOLECULAR MEDICINE (BERLIN), vol. 78, no. 12, 2001, pages 673 - 683, XP002187721, ISSN: 0946-2716
APPELBAUM FREDERICK R: "Haematopoietic cell transplantation as immunotheraphy.", NATURE (LONDON), vol. 411, no. 6835, 2001, pages 385 - 389, XP002187722, ISSN: 0028-0836
LU L ET AL: "ADENOVIRAL DELIVERY OF CTLA4LG INTO MYELOID DENDRITIC CELLS PROMOTES THEIR IN VITRO TOLEROGENICITY AND SURVIVAL IN ALLOGENEIC RECIPIENTS", GENE THERAPY, MACMILLAN PRESS LTD., BASINGSTOKE, GB, vol. 6, no. 4, 1999, pages 554 - 563, XP000946114, ISSN: 0969-7128
BLAZAR BRUCE R ET AL: "CD4+ T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand (CD40L:CD154) antibody lose their graft-versus-host disease lethality capacity but retain nominal antigen responses.", JOURNAL OF CLINICAL INVESTIGATION, vol. 102, no. 3, 1 August 1998 (1998-08-01), pages 473 - 482, XP002187718, ISSN: 0021-9738
ZELLER ET AL: "Induction of CD4+ T Cell Alloanitgen-Specific Hyporesponsiveness by Il-10 and TGF-beta", THE JOURNAL OF IMMUNOLOGY, vol. 163, 1999, pages 3684 - 3691, XP002187719
CHAMPLIN RICHARD ET AL: "Harnessing graft-versus-malignancy: Non-myeloablative preparative regimens for allogeneic haematopoietic transplantation, an evolving strategy for adoptive immunotherapy.", BRITISH JOURNAL OF HAEMATOLOGY, vol. 111, no. 1, October 2000 (2000-10-01), pages 18 - 29, XP002187720, ISSN: 0007-1048
APPLEMAN LEONARD J ET AL: "Helper T cell anergy: From biochemistry to cancer pathophysiology and therapeutics.", JOURNAL OF MOLECULAR MEDICINE (BERLIN), vol. 78, no. 12, 2001, pages 673 - 683, XP002187721, ISSN: 0946-2716
APPELBAUM FREDERICK R: "Haematopoietic cell transplantation as immunotheraphy.", NATURE (LONDON), vol. 411, no. 6835, 2001, pages 385 - 389, XP002187722, ISSN: 0028-0836
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