Title:
EXCIPIENTS FOR PURIFICATION AND VIRUS FILTRATION OF BIOLOGICAL FLUIDS
Document Type and Number:
WIPO Patent Application WO/2023/217813
Kind Code:
A3
Abstract:
Methods are disclosed for filtering a biological fluid that includes housing a surface treated porous membrane in a filtration device, optionally a virus filtration device, having an input and an output; introducing a biological fluid into the input of the filtration device wherein an aromatic excipient is added to the biological fluid; and collecting a filtrate from the output. In some embodiments, the biological fluid comprises a monoclonal antibody solution, a protein-containing solution, a solution containing fragment antigen-binding fragments, a solution containing recombinant proteins, or a fractionated plasma product.
Inventors:
CACACE BENJAMIN (US)
ELDO JOBY (US)
CARBRELLO CHRISTINA (US)
ROSENKRANZ TOBIAS (DE)
ELDO JOBY (US)
CARBRELLO CHRISTINA (US)
ROSENKRANZ TOBIAS (DE)
Application Number:
PCT/EP2023/062340
Publication Date:
March 14, 2024
Filing Date:
May 10, 2023
Export Citation:
Assignee:
MERCK PATENT GMBH (DE)
International Classes:
B01D61/14; B01D61/16; B01D67/00; B01D69/02; B01D71/40
Domestic Patent References:
| WO2015196091A1 | 2015-12-23 | |||
| WO2000045941A1 | 2000-08-10 |
Foreign References:
| CN102000517B | 2013-07-03 |
Other References:
MU L J ET AL: "Hydrophilic modification of polyethersulfone porous membranes via a thermal-induced surface crosslinking approach", APPLIED SURFACE SCIENCE, ELSEVIER, AMSTERDAM , NL, vol. 255, no. 16, 30 May 2009 (2009-05-30), pages 7273 - 7278, XP026117590, ISSN: 0169-4332, [retrieved on 20090401], DOI: 10.1016/J.APSUSC.2009.03.081
ELAHEH BINABAJI ET AL: "Ultrafiltration of highly concentrated antibody solutions: Experiments and modeling for the effects of module and buffer conditions", BIOTECHNOLOGY PROGRESS, AMERICAN CHEMICAL SOCIETY, HOBOKEN, USA, vol. 32, no. 3, 17 May 2016 (2016-05-17), pages 692 - 701, XP072291646, ISSN: 8756-7938, DOI: 10.1002/BTPR.2252
ELAHEH BINABAJI ET AL: "Ultrafiltration of highly concentrated antibody solutions: Experiments and modeling for the effects of module and buffer conditions", BIOTECHNOLOGY PROGRESS, AMERICAN CHEMICAL SOCIETY, HOBOKEN, USA, vol. 32, no. 3, 17 May 2016 (2016-05-17), pages 692 - 701, XP072291646, ISSN: 8756-7938, DOI: 10.1002/BTPR.2252
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