Title:
EXENATIDE ANALOG
Document Type and Number:
WIPO Patent Application WO/2020/108228
Kind Code:
A1
Abstract:
The present invention belongs to the field of biomedicine, and specifically discloses an exenatide analog. The present invention makes a design for several amino acid structures at the C-terminus of the amino acid sequence of exenatide Exendin-4, including the addition or deletion of amino acids, amino acid sequence mutations and addition of sites that can be used for site-directed modification to obtain an exenatide analog. The activity of this analog to stimulate insulin secretion from mouse islet tumor cells is significantly higher than exenatide Ex-4, and the glucose-lowering activity in vivo in diabetic model mouse C57BL/KsJ-db/db is significantly better than exenatide Ex-4, which can be used to prevent, treat or reduce diabetes and obesity and/or related complications thereof and other diseases.
Inventors:
ZHANG GUIMIN (CN)
LI TIEJIAN (CN)
LIU DONG (CN)
LI TIEJIAN (CN)
LIU DONG (CN)
Application Number:
PCT/CN2019/115200
Publication Date:
June 04, 2020
Filing Date:
November 03, 2019
Export Citation:
Assignee:
LUNAN BETTER PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K14/605; A61K38/26; A61P5/48
Foreign References:
| CN101993485A | 2011-03-30 | |||
| EP1908778A1 | 2008-04-09 |
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