EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS

WIPO Patent Application WO2006076415

A3

The application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following. (I)

WU GEORGE G (US)
SUDHAKAR ANANTHA (US)
WANG TAO (US)
XIE JI (US)
CHEN FRANK XING (US)
POIRIER MARC (US)
HUANG MINGSHENG (US)
SABESAN VIJAY (US)
KWOK DAW-LONG (US)
CUI JIAN (US)
YANG XIAOJING (US)
THIRUVENGADAM TIRUVETTIPURAM K (US)
LIAO JING (US)
ZAVIALOV ILIA (US)
NGUYEN HOA N (US)
LIM NGIAP KIE (US)

PCT/US2006/000954

November 16, 2006

January 12, 2006

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SCHERING CORP (US)
WU GEORGE G (US)
SUDHAKAR ANANTHA (US)
WANG TAO (US)
XIE JI (US)
CHEN FRANK XING (US)
POIRIER MARC (US)
HUANG MINGSHENG (US)
SABESAN VIJAY (US)
KWOK DAW-LONG (US)
CUI JIAN (US)
YANG XIAOJING (US)
THIRUVENGADAM TIRUVETTIPURAM K (US)
LIAO JING (US)
ZAVIALOV ILIA (US)
NGUYEN HOA N (US)
LIM NGIAP KIE (US)

C07D307/92; C07C69/54; C07C69/606; C07C205/44; C07C205/55; C07C235/28; C07C309/08; C07D235/12; C07D263/56; C07D277/64; C07D405/06; C07D413/06; C07D417/06; C07F9/58

US20030216437A1	2003-11-20
US6063847A	2000-05-16

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