Title:
EXOGENOUS GENE CONTROLLABLE EXPRESSION VIRUS PACKAGING VECTOR AND PACKAGING METHOD
Document Type and Number:
WIPO Patent Application WO/2022/121855
Kind Code:
A1
Abstract:
The present application relates to the technical field of biology, and specifically, to an exogenous gene controllable expression virus packaging vector and a packaging method. The virus packaging vector has two ITR fragments and a gene expression cassette inserted between the two ITR fragments. The gene expression cassette comprises a promoter, a repressor operator, and an optional target gene that are connected in sequence. When there is a repressor, the repressor operator can repress the expression of a downstream target gene thereof.
Inventors:
YANG XINGLIN (CN)
YANG JIALI (CN)
YANG RUIJU (CN)
JIA GUODONG (CN)
YOU QINGRUI (CN)
YANG JIALI (CN)
YANG RUIJU (CN)
JIA GUODONG (CN)
YOU QINGRUI (CN)
Application Number:
PCT/CN2021/135817
Publication Date:
June 16, 2022
Filing Date:
December 06, 2021
Export Citation:
Assignee:
OBIO TECH SHANGHAI CORP LTD (CN)
International Classes:
C12N5/10; C12N15/86; C12N15/861; C12N15/864
Domestic Patent References:
| WO2020161484A1 | 2020-08-13 |
Foreign References:
| CN111733184A | 2020-10-02 | |||
| US20080311618A1 | 2008-12-18 |
Other References:
H. E. MAUNDER, J. WRIGHT, B. R. KOLLI, C. R. VIEIRA, T. T. MKANDAWIRE, S. TATORIS, V. KENNEDY, S. IQBALL, G. DEVARAJAN, S. ELLIS, : "Enhancing titres of therapeutic viral vectors using the transgene repression in vector production (TRiP) system", NATURE COMMUNICATIONS, vol. 8, no. 1, 1 April 2017 (2017-04-01), XP055734707, DOI: 10.1038/ncomms14834
Attorney, Agent or Firm:
ADVANCE CHINA IP LAW OFFICE (CN)
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