Title:
EXOSOME PRODUCTION PROMOTER
Document Type and Number:
WIPO Patent Application WO/2018/212250
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an exosome production promoter with which exosome production can be easily promoted.
The exosome production promoter contains ceramide as an active ingredient.
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Inventors:
MUKAI KATSUYUKI (JP)
YUYAMA KOHEI (JP)
IGARASHI YASUYUKI (JP)
YUYAMA KOHEI (JP)
IGARASHI YASUYUKI (JP)
Application Number:
PCT/JP2018/018981
Publication Date:
November 22, 2018
Filing Date:
May 16, 2018
Export Citation:
Assignee:
DAICEL CORP (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
A61K31/164; A23L33/105; A23L33/115; A61P25/28; A61P43/00
Foreign References:
| JPH08113535A | 1996-05-07 |
Other References:
YUYAMA, K. ET AL.: "Sphingolipid-modulated exosome secretion promotes clearance of amyloid- beta by microglia", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 287, no. 14, 2012, pages 10977 - 10989, XP055200773, ISSN: 0021-9258, DOI: doi:10.1074/jbc.M111.324616
DINKINS, M. B. ET AL.: "The 5XFAD Mouse Model of Alzheimer's Disease Exhibits an Age-Dependent Increase in Anti-Ceramide IgG and Exogenous Administration of Ceramide Further Increases Anti-Ceramide Titers and Amyloid Plaque Burden", JOURNAL OF ALZHEIMER' S DISEASE, vol. 46, no. 1, 2015, pages 55 - 61, ISSN: 1387-2877
SUGAWARA ET AL: "Digestion and Absorption of Sphingolipids as Functional Food Components", JOURNAL OF JAPANES SOCIETY OF NUTRICION AND FOOD SCIENCE, vol. 66, no. 4, 2013, pages 177 - 183, XP055612857
LIU, L. ET AL.: "Abstracts: P-VIII-3. Modulation of exosome release from endothelial cells causes alterations in cell proliferation and miRNA-126 expression", JOURNAL OF EXTRACELLULAR VESICLES, vol. 4, no. 1, 2015, pages 91 - 92, XP055612876
KONG, J. ET AL.: "Ceramide-induced secretion of exosome-associated breast cancer resistance protein and reduction of doxorubicin resistance in human breast cancer MDAMB-231 cells.", MOLECULAR BIOLOGY OF THE CELL, vol. 25, no. 25, 2014, ISSN: 1059-1524
GOODMAN, Y. ET AL.: "Ceramide Protects Hippocampal Neurons Against Excitotoxic and Oxidative Insults, and Amyloid beta -Peptide Toxicity", JOURNAL OF NEUROCHEMISTRY, vol. 66, no. 2, 1996, pages 869 - 872, XP055597993, ISSN: 0022-3042
YUYAMA, K. ET AL.: "Abstract: PF07.04. In vitro and in vivo effects of plant ceramide to increase exosomes capable of eliminating Alzheimer's amyloid-beta", JOURNAL OF EXTRACELLULAR VESICLES, vol. 7, no. 1, 30 April 2018 (2018-04-30), pages 157, XP055612892
TAKAHASHI, ET AL: "Abstract: 3B03p03. Preventive effects of dietary konjac ceramide on the Alzheimer's brain", ANNUAL MEETING OF THE JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, 2018, 5 March 2018 (2018-03-05), pages 1810, ISSN: 2186-7976
DINKINS, M. B. ET AL.: "The 5XFAD Mouse Model of Alzheimer's Disease Exhibits an Age-Dependent Increase in Anti-Ceramide IgG and Exogenous Administration of Ceramide Further Increases Anti-Ceramide Titers and Amyloid Plaque Burden", JOURNAL OF ALZHEIMER' S DISEASE, vol. 46, no. 1, 2015, pages 55 - 61, ISSN: 1387-2877
SUGAWARA ET AL: "Digestion and Absorption of Sphingolipids as Functional Food Components", JOURNAL OF JAPANES SOCIETY OF NUTRICION AND FOOD SCIENCE, vol. 66, no. 4, 2013, pages 177 - 183, XP055612857
LIU, L. ET AL.: "Abstracts: P-VIII-3. Modulation of exosome release from endothelial cells causes alterations in cell proliferation and miRNA-126 expression", JOURNAL OF EXTRACELLULAR VESICLES, vol. 4, no. 1, 2015, pages 91 - 92, XP055612876
KONG, J. ET AL.: "Ceramide-induced secretion of exosome-associated breast cancer resistance protein and reduction of doxorubicin resistance in human breast cancer MDAMB-231 cells.", MOLECULAR BIOLOGY OF THE CELL, vol. 25, no. 25, 2014, ISSN: 1059-1524
GOODMAN, Y. ET AL.: "Ceramide Protects Hippocampal Neurons Against Excitotoxic and Oxidative Insults, and Amyloid beta -Peptide Toxicity", JOURNAL OF NEUROCHEMISTRY, vol. 66, no. 2, 1996, pages 869 - 872, XP055597993, ISSN: 0022-3042
YUYAMA, K. ET AL.: "Abstract: PF07.04. In vitro and in vivo effects of plant ceramide to increase exosomes capable of eliminating Alzheimer's amyloid-beta", JOURNAL OF EXTRACELLULAR VESICLES, vol. 7, no. 1, 30 April 2018 (2018-04-30), pages 157, XP055612892
TAKAHASHI, ET AL: "Abstract: 3B03p03. Preventive effects of dietary konjac ceramide on the Alzheimer's brain", ANNUAL MEETING OF THE JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, 2018, 5 March 2018 (2018-03-05), pages 1810, ISSN: 2186-7976
Attorney, Agent or Firm:
TANAKA, Junya et al. (JP)
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