EXOSOMES FOR TARGET SPECIFIC DELIVERY AND METHODS FOR PREPARING AND DELIVERING THE SAME

WIPO Patent Application WO/2019/035057

A3

The present invention provides a method for producing an exosome that transfers an active substance specifically to a target and the exosome produced by the same; a method for delivering the active substance to the target tissue using the exosome; a pharmaceutical composition for delivery of the active substance comprising the exosome as an active ingredient; and a composition for preparing the exosome comprising an expression vector wherein the target peptide is inserted into an extracellular portion of a transmembrane protein.

CHOI CHULHEE (KR)
YIM NAMBIN (KR)
CHOI HOJUN (KR)
CHOI KYUNGSUN (KR)
RYU SEUNG-WOOK (KR)

PCT/IB2018/056200

April 25, 2019

August 16, 2018

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CELLEX LIFE SCIENCES INCORPORATED (KR)

A61K47/69; A61K38/00; C07K14/705

WO2015002956A1

2015-01-08

KR20160130937A	2016-11-15
US20160137716A1	2016-05-19

HA, DINH ET AL.: "Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges", ACTA PHARMACEUTICA SINICA B, vol. 6, no. 4, 2016, pages 287 - 296, XP055303644, DOI: doi:10.1016/j.apsb.2016.02.001
KOTMAKCI, MUSTAFA ET AL.: "Extracellular vesicles as natural nanosized delivery systems for small-molecule drugs and genetic material: steps towards the future nanomedicines", JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES, vol. 18, no. 3, 2015, pages 396 - 413, XP055594743

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