Title:
EXPANSION OF STEM/PROGENITOR CELLS BY INHIBITION OF ENZYMATIC REACTIONS CATALYZED BY THE SIR2 FAMILY OF ENZYMES
Document Type and Number:
WIPO Patent Application WO2006006171
Kind Code:
A3
Abstract:
Provided are ex vivo and in vivo methods of expanding renewable stem cells using agents capable of down-regulating Sir2 protein activity and/or expression, expanded populations of renewable stem cells, and uses thereof.
Inventors:
PELED TONY (IL)
Application Number:
PCT/IL2005/000753
Publication Date:
April 06, 2006
Filing Date:
July 14, 2005
Export Citation:
Assignee:
GAMIDA CELL LTD (IL)
PELED TONY (IL)
PELED TONY (IL)
International Classes:
C12N9/10; C12N5/0789; C12N5/22
Domestic Patent References:
| WO2004087885A2 | 2004-10-14 |
Other References:
HISAHARA S ET AL: "Effects of histone deacetylase sir2alpha on proliferation and differentiation of neural stem cells.", SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, vol. 2003, 2003, & 33RD ANNUAL MEETING OF THE SOCIETY OF NEUROSCIENCE; NEW ORLEANS, LA, USA; NOVEMBER 08-12, 2003, pages Abstract No. 242.12 URL - http://sf, XP009055774
HORIO YOSHIYUKI ET AL: "Functional analysis of SIR2.", FOLIA PHARMACOLOGICA JAPONICA, vol. 122, no. 1, 2003, pages 30P - 32P, XP009055777, ISSN: 0015-5691
HORIO YOSHIYUKI ET AL: "Histone decetylase Sir2alpha affects proliferation and differentiation of neural stem cells.", JOURNAL OF PHARMACOLOGICAL SCIENCES, vol. 94, no. Supplement 1, 2004, & 77TH ANNUAL MEETING OF THE JAPANESE PHARMACOLOGICAL SOCIETY; OSAKA, JAPAN; MARCH 08-10, 2004, pages 49P, XP009055776, ISSN: 1347-8613
NG YUK YIN ET AL: "Selective in vitro expansion and efficient retroviral transduction of human CD34+ CD38- haematopoietic stem cells", BRITISH JOURNAL OF HAEMATOLOGY, vol. 117, no. 1, April 2002 (2002-04-01), pages 226 - 237, XP002350533, ISSN: 0007-1048
KYRYLENKO S ET AL: "DIFFERENTIAL REGULATION OF THE SIR2 HISTONE DEACETYLASE GENE FAMILY BY INHIBITORS OF CLASS I AND II HISTONE DEACETYLASES", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES, BIRKHAUSER VERLAG, BASEL, CH, vol. 60, no. 9, September 2003 (2003-09-01), pages 1990 - 1997, XP001206834, ISSN: 1420-682X
TRAVERS H ET AL: "Human CD34+ hematopoietic progenitor cells hyperacetylate core histones in response to sodium butyrate, but not trichostatin A", EXPERIMENTAL CELL RESEARCH, SAN DIEGO, CA, US, vol. 280, no. 2, 1 November 2002 (2002-11-01), pages 149 - 158, XP002977131, ISSN: 0014-4827
BLANDER G ET AL: "THE SIR2 FAMILY OF PROTEIN DEACETYLASES", ANNUAL REVIEW OF BIOCHEMISTRY, PALTO ALTO, CA, US, vol. 73, 2004, pages 417 - 435, XP001206836, ISSN: 0066-4154
BEDALOV ANTONIO ET AL: "Identification of a small molecule inhibitor of Sir2p", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 98, no. 26, 18 December 2001 (2001-12-18), pages 15113 - 15118, XP002350537, ISSN: 0027-8424
HIRAO MAKI ET AL: "Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 52, 26 December 2003 (2003-12-26), pages 52773 - 52782, XP002350538, ISSN: 0021-9258
MCBURNEY MICHAEL W ET AL: "The absence of SIR2alpha protein has no effect on global gene silencing in mouse embryonic stem cells.", MOLECULAR CANCER RESEARCH, vol. 1, no. 5, March 2003 (2003-03-01), pages 402 - 409, XP002350539, ISSN: 1541-7786
MCBURNEY MICHAEL W ET AL: "The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis.", MOLECULAR AND CELLULAR BIOLOGY, vol. 23, no. 1, January 2003 (2003-01-01), pages 38 - 54, XP002363976, ISSN: 0270-7306
MOTTA MARIA CARLA ET AL: "Mammalian SIRT1 represses forkhead transcription factors.", CELL, vol. 116, no. 4, 20 February 2004 (2004-02-20), pages 551 - 563, XP002363977, ISSN: 0092-8674
INDEN MASATOSHI ET AL: "Pharmacological characteristics of rotational behavior in hemiparkinsonian rats transplanted with mouse embryonic stem cell-derived neurons", JOURNAL OF PHARMACOLOGICAL SCIENCES, vol. 96, no. 1, September 2004 (2004-09-01), pages 53 - 64, XP002363978, ISSN: 1347-8613
CHEN LI-BO ET AL: "Differentiation of rat marrow mesenchymal stem cells into pancreatic islet beta-cells.", WORLD JOURNAL OF GASTROENTEROLOGY : WJG. 15 OCT 2004, vol. 10, no. 20, 15 October 2004 (2004-10-15), pages 3016 - 3020, XP002363979, ISSN: 1007-9327
HORIO YOSHIYUKI ET AL: "Functional analysis of SIR2.", FOLIA PHARMACOLOGICA JAPONICA, vol. 122, no. 1, 2003, pages 30P - 32P, XP009055777, ISSN: 0015-5691
HORIO YOSHIYUKI ET AL: "Histone decetylase Sir2alpha affects proliferation and differentiation of neural stem cells.", JOURNAL OF PHARMACOLOGICAL SCIENCES, vol. 94, no. Supplement 1, 2004, & 77TH ANNUAL MEETING OF THE JAPANESE PHARMACOLOGICAL SOCIETY; OSAKA, JAPAN; MARCH 08-10, 2004, pages 49P, XP009055776, ISSN: 1347-8613
NG YUK YIN ET AL: "Selective in vitro expansion and efficient retroviral transduction of human CD34+ CD38- haematopoietic stem cells", BRITISH JOURNAL OF HAEMATOLOGY, vol. 117, no. 1, April 2002 (2002-04-01), pages 226 - 237, XP002350533, ISSN: 0007-1048
KYRYLENKO S ET AL: "DIFFERENTIAL REGULATION OF THE SIR2 HISTONE DEACETYLASE GENE FAMILY BY INHIBITORS OF CLASS I AND II HISTONE DEACETYLASES", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES, BIRKHAUSER VERLAG, BASEL, CH, vol. 60, no. 9, September 2003 (2003-09-01), pages 1990 - 1997, XP001206834, ISSN: 1420-682X
TRAVERS H ET AL: "Human CD34+ hematopoietic progenitor cells hyperacetylate core histones in response to sodium butyrate, but not trichostatin A", EXPERIMENTAL CELL RESEARCH, SAN DIEGO, CA, US, vol. 280, no. 2, 1 November 2002 (2002-11-01), pages 149 - 158, XP002977131, ISSN: 0014-4827
BLANDER G ET AL: "THE SIR2 FAMILY OF PROTEIN DEACETYLASES", ANNUAL REVIEW OF BIOCHEMISTRY, PALTO ALTO, CA, US, vol. 73, 2004, pages 417 - 435, XP001206836, ISSN: 0066-4154
BEDALOV ANTONIO ET AL: "Identification of a small molecule inhibitor of Sir2p", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 98, no. 26, 18 December 2001 (2001-12-18), pages 15113 - 15118, XP002350537, ISSN: 0027-8424
HIRAO MAKI ET AL: "Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 52, 26 December 2003 (2003-12-26), pages 52773 - 52782, XP002350538, ISSN: 0021-9258
MCBURNEY MICHAEL W ET AL: "The absence of SIR2alpha protein has no effect on global gene silencing in mouse embryonic stem cells.", MOLECULAR CANCER RESEARCH, vol. 1, no. 5, March 2003 (2003-03-01), pages 402 - 409, XP002350539, ISSN: 1541-7786
MCBURNEY MICHAEL W ET AL: "The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis.", MOLECULAR AND CELLULAR BIOLOGY, vol. 23, no. 1, January 2003 (2003-01-01), pages 38 - 54, XP002363976, ISSN: 0270-7306
MOTTA MARIA CARLA ET AL: "Mammalian SIRT1 represses forkhead transcription factors.", CELL, vol. 116, no. 4, 20 February 2004 (2004-02-20), pages 551 - 563, XP002363977, ISSN: 0092-8674
INDEN MASATOSHI ET AL: "Pharmacological characteristics of rotational behavior in hemiparkinsonian rats transplanted with mouse embryonic stem cell-derived neurons", JOURNAL OF PHARMACOLOGICAL SCIENCES, vol. 96, no. 1, September 2004 (2004-09-01), pages 53 - 64, XP002363978, ISSN: 1347-8613
CHEN LI-BO ET AL: "Differentiation of rat marrow mesenchymal stem cells into pancreatic islet beta-cells.", WORLD JOURNAL OF GASTROENTEROLOGY : WJG. 15 OCT 2004, vol. 10, no. 20, 15 October 2004 (2004-10-15), pages 3016 - 3020, XP002363979, ISSN: 1007-9327
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