Title:
EXPEDIENT SYNTHESIS OF OSELTAMIVIR AND RELATED COMPOUNDS VIA DIRECT OLEFIN DIAZIDATION-DIAMIDATION REACTION
Document Type and Number:
WIPO Patent Application WO/2019/191363
Kind Code:
A3
Abstract:
Disclosed herein are improved methods for the preparation of oseltamivir, and intermediates useful thereto.
Inventors:
XU HAO (US)
LI HONGZE (US)
SHEN SHOUJIE (US)
ZHU CHENGLIANG (US)
LI HONGZE (US)
SHEN SHOUJIE (US)
ZHU CHENGLIANG (US)
Application Number:
PCT/US2019/024481
Publication Date:
December 05, 2019
Filing Date:
March 28, 2019
Export Citation:
Assignee:
UNIV GEORGIA STATE RES FOUND (US)
International Classes:
C07C201/12; C07C205/59; C07C247/18
Domestic Patent References:
| WO2009078813A1 | 2009-06-25 |
Foreign References:
| US20160222029A1 | 2016-08-04 | |||
| EP1127872A1 | 2001-08-29 |
Other References:
SHIN, C. -G. ET AL.: "α,β-Unsaturated Carboxylic Acid Derivatives. XVI. Synthesis and Configuration of Diels-Alder Adducts from Ethyl 3-Nitro-2-alkenoate and 1,3-Butadiene", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 51, no. 9, 1978, pages 2618 - 2621, XP055659630
SULLIVAN, B. ET AL.: "Symmetry-Based Design for the Chemoenzymatic Synthesis of Oseltamivir (Tamiflu) from Ethyl Benzoate", ANGEW. CHEM. INT. ED., vol. 48, 2009, pages 4229 - 4231, XP055659633
LI, H. ET AL.: "Enantioselective Synthesis of Oseltamivir Phosphate (Tamiflu) via the Iron-Catalyzed Stereoselective Olefin Diazidation", J. AM. CHEM. SOC., vol. 140, 24 July 2018 (2018-07-24), pages 10619 - 10626, XP055659635
SULLIVAN, B. ET AL.: "Symmetry-Based Design for the Chemoenzymatic Synthesis of Oseltamivir (Tamiflu) from Ethyl Benzoate", ANGEW. CHEM. INT. ED., vol. 48, 2009, pages 4229 - 4231, XP055659633
LI, H. ET AL.: "Enantioselective Synthesis of Oseltamivir Phosphate (Tamiflu) via the Iron-Catalyzed Stereoselective Olefin Diazidation", J. AM. CHEM. SOC., vol. 140, 24 July 2018 (2018-07-24), pages 10619 - 10626, XP055659635
Attorney, Agent or Firm:
CUTCHINS, William W. et al. (US)
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