EXPRESSION CLONING METHOD - WHITEHEAD BIOMEDICAL INST

Title:

EXPRESSION CLONING METHOD

Document Type and Number:

WIPO Patent Application WO2002059299

Kind Code:

A9

Abstract:

Described herein is a method of expression cloning useful for identifying and obtaining proteins involved in GLUT4 trafficking in mammalian cells and, thus, in insulin-stimulated glucose uptake by such cells. In particular, an enrichment strategy for expression cloning proteins involved in GLUT4 trafficking at the plasma membrane is described. Proteins identified by the method and uses therefore are also described.

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Inventors:

BOGAN JONATHAN S (US)
LODISH HARVEY F (US)

Application Number:

PCT/US2002/002392

Publication Date:

August 12, 2004

Filing Date:

January 28, 2002

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Assignee:

WHITEHEAD BIOMEDICAL INST (US)
GEN HOSPITAL CORP (US)
BOGAN JONATHAN S (US)
LODISH HARVEY F (US)

International Classes:

C07K14/47; C07K16/44; C12N15/10; C12N15/12; G01N33/58; G01N33/68; (IPC1-7): C12N15/10; C07K14/705; C07K16/28; C12N15/12; G01N33/53

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