EXPRESSION OF IMMUNOGENIC HEPATITIS B SURFACE ANTIGENS IN TRANSGENIC PLANTS

Title:

EXPRESSION OF IMMUNOGENIC HEPATITIS B SURFACE ANTIGENS IN TRANSGENIC PLANTS

Document Type and Number:

WIPO Patent Application WO2000037610

Kind Code:

A3

Abstract:

Plant expression vectors comprising at least two expression cassettes are provided which function to reduce transcriptional silencing of polynucleotide expression. Further, novel plant expression vectors for expression of immunogenic polypeptides, including HBsAg, are provided. The plant expression vectors can be used to produce immunogenic polypeptides, including HBsAg, in edible plant tissues. The edible plant tissues can be used to elicit an immune response in humans and animals when the plant tissues are consumed.

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Inventors:

MASON HUGH S (US)
THANAVALA YASMIN (US)
ARNTZEN CHARLES JOEL (US)
RICHTER ELIZABETH (US)

Application Number:

PCT/US1999/031020

Publication Date:

June 13, 2002

Filing Date:

December 23, 1999

Export Citation:

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Assignee:

THOMPSON BOYCE PLANT RES (US)
HEALTH RES INST (US)
MASON HUGH S (US)
THANAVALA YASMIN (US)
ARNTZEN CHARLES JOEL (US)
RICHTER ELIZABETH (US)

International Classes:

A01H5/00; A61K36/23; A61K36/81; A61K39/00; A61P31/12; C07K14/02; C12N1/21; C12N5/10; C12N15/09; C12N15/51; C12N15/82; C12R1/19; C12R1/91; (IPC1-7): C07H21/04; C12N15/36; C12N5/04; A61K48/00; C07K1/14; A01H1/00

Domestic Patent References:

WO1996012801A1

1996-05-02

Foreign References:

US5380831A	1995-01-10
US5484719A	1996-01-16
US5612487A	1997-03-18

Other References:

MASON H.S. ET AL.: "Expression of hepatitis B surface antigen in transgenic plants", PROC. NATL. ACAD. SCI. USA, vol. 89, December 1992 (1992-12-01), pages 11745 - 11749, XP002001660
DE AIZPURUA ET AL.: "Oral vaccination identification of classes of proteins that provoke an immune response upon oral feeding", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 167, February 1988 (1988-02-01), pages 440 - 451, XP000618949

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