Title:
EXPRESSION OF VOLTAGE-GATED ION CHANNELS IN CILIATES
Document Type and Number:
WIPO Patent Application WO/2015/171643
Kind Code:
A3
Abstract:
Methods are disclosed for the production of mammalian voltage-gated ion channels in ciliates. In other aspects, compositions comprising lipid bilayers containing mammalian voltage-gated ion channels are disclosed. In other aspects, compositions comprising purified and reconstituted mammalian voltage-gated ion channels are disclosed.
Inventors:
COLUSSI PAUL (US)
PAPOYAN ASHOT (US)
BISHARYAN YELENA (US)
BEDNENKO JANNA (US)
CLARK THEODORE G (US)
PAPOYAN ASHOT (US)
BISHARYAN YELENA (US)
BEDNENKO JANNA (US)
CLARK THEODORE G (US)
Application Number:
PCT/US2015/029290
Publication Date:
May 26, 2016
Filing Date:
May 05, 2015
Export Citation:
Assignee:
TETRAGENETICS INC (US)
International Classes:
C12P21/06; C12N1/10; C12N15/00
Domestic Patent References:
| WO2011119498A1 | 2011-09-29 |
Foreign References:
| US20050202539A1 | 2005-09-15 | |||
| US20050032165A1 | 2005-02-10 | |||
| US20090175784A1 | 2009-07-09 |
Other References:
JAVAUX ET AL.: "Recognizing and interpreting the fossils of early eukaryotes", ORIGINS OF LIFE AND EVOLUTION OF THE BIOSPHERE, vol. 33, no. 1, February 2003 (2003-02-01), pages 75 - 94, XP055360435
BENNETT ET AL.: "Isoform-specific effects of sialic acid on voltage-dependent Na+ channel gating: functional sialic acids are localized to the S5-S6 loop of domain I", JOURNAL OF PHYSIOLOGY, vol. 538, no. 3, 2002, pages 675 - 690, XP055360441
BENNETT ET AL.: "Isoform-specific effects of sialic acid on voltage-dependent Na+ channel gating: functional sialic acids are localized to the S5-S6 loop of domain I", JOURNAL OF PHYSIOLOGY, vol. 538, no. 3, 2002, pages 675 - 690, XP055360441
Attorney, Agent or Firm:
TWOMEY, Michael, J. et al. (60 State StreetBoston, MA, US)
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