Title:
EXTENDED RELEASE PARTICLES, METHOD FOR PRODUCING SAME, MOLDING MATERIAL AND MOLDED ARTICLE
Document Type and Number:
WIPO Patent Application WO/2015/030213
Kind Code:
A1
Abstract:
This method for producing extended release particles (1) comprises: an oil phase component preparation step wherein an oil phase component containing a hydrophobic slurry is prepared by dispersing an antibiotically active compound, which is hydrophobic and substantially insoluble in a hydrophobic polymerizable vinyl monomer, in a hydrophobic polymerizable vinyl monomer in the absence of a solvent; a water dispersion step wherein a water dispersion liquid is prepared by dispersing the hydrophobic slurry in water; and a polymerization step wherein the polymerizable vinyl monomer is subjected to suspension polymerization, thereby producing a polymer.
Inventors:
OSHIMA JUNJI (JP)
INOUE HIDEAKI (JP)
HOSHINO TOMOKO (JP)
KOBAYASHI AYAKO (JP)
INOUE HIDEAKI (JP)
HOSHINO TOMOKO (JP)
KOBAYASHI AYAKO (JP)
Application Number:
PCT/JP2014/072837
Publication Date:
March 05, 2015
Filing Date:
August 29, 2014
Export Citation:
Assignee:
JAPAN ENVIRO CHEMICALS LTD (JP)
International Classes:
A01N25/10; A01N25/12; A01N51/00; A01P7/04; C08F2/18; C08F2/44
Domestic Patent References:
WO2012124599A1 | 2012-09-20 | |||
WO2012124598A1 | 2012-09-20 | |||
WO2001041927A1 | 2001-06-14 | |||
WO2014010435A1 | 2014-01-16 |
Foreign References:
JP2011079816A | 2011-04-21 | |||
JP2002503679A | 2002-02-05 | |||
JPS61236702A | 1986-10-22 | |||
JP2002513038A | 2002-05-08 | |||
JPS59145265A | 1984-08-20 | |||
JP2004331625A | 2004-11-25 | |||
JP2002513039A | 2002-05-08 | |||
JPH09136808A | 1997-05-27 | |||
JPH06172684A | 1994-06-21 | |||
JPH06166733A | 1994-06-14 | |||
JP2014019655A | 2014-02-03 |
Other References:
S.M.ICONOMOPOULOU ET AL.: "Incorporation of low molecular weight biocides into polystyrene- divinyl benzene beads with controlled release characteristics", JOURNAL OF CONTROLLED RELEASE, vol. 102, no. 1, 2005, pages 223 - 233
P.SPEISER ET AL.: "Pearl polymerizates, a new perorally administered form and the effect of pharmaceuticals on them", PRAEPARATIVE PHARMAZIE, vol. 6, no. 9-10, 1970, pages 149 - 154
S.P.VYAS ET AL.: "Formulation of sustained release nitrofurantoin by interfacial copolymerization method", INDIAN DRUGS, vol. 18, no. 1, 1980, pages 8 - 10
M.A.M.OLIVEIRA ET AL.: "In-Situ Incorporation of Amoxicillin in PVA/PVAc-co-PMMA Particles during Suspension Polymerizations", MACROMOLECULAR SYMPOSIA, vol. 299, no. 300, 2011, pages 34 - 40
M.YOSHIDA ET AL.: "Preparation of microspheres for slow release drug by radiation-induced suspension polymerization and their properties", YAKUZAIGAKU, vol. 42, no. 3, 1982, pages 137 - 145
A.ARUN ET AL.: "In vitro drug release studies of 2-hydroxyethyl acrylate or 2-hydroxypropyl methacrylate-4-{(1E,4E)-5-[4-(acryloyloxy) phenyl]-3-oxopenta-1,4-dienyl)phenyl acrylate copolymer beads", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B: APPLIED BIOMATERIALS, vol. 73 B, no. 2, 2005, pages 291 - 300
TAKAYUKI TAKEI ET AL.: "Preparation of Polymeric Microspheres for Controlled Release of Acetamiprid", KAGAKU KOGAKU RONBUNSHU, vol. 39, no. 3, 20 July 2013 (2013-07-20), pages 219 - 223
E.JABBARI ET AL.: "Morphology of and release behavior from porous polyurethane microspheres", BIOMATERIALS, vol. 21, no. 20, 2000, pages 2073 - 2079
P.SPEISER ET AL.: "Pearl polymerizates, a new perorally administered form and the effect of pharmaceuticals on them", PRAEPARATIVE PHARMAZIE, vol. 6, no. 9-10, 1970, pages 149 - 154
S.P.VYAS ET AL.: "Formulation of sustained release nitrofurantoin by interfacial copolymerization method", INDIAN DRUGS, vol. 18, no. 1, 1980, pages 8 - 10
M.A.M.OLIVEIRA ET AL.: "In-Situ Incorporation of Amoxicillin in PVA/PVAc-co-PMMA Particles during Suspension Polymerizations", MACROMOLECULAR SYMPOSIA, vol. 299, no. 300, 2011, pages 34 - 40
M.YOSHIDA ET AL.: "Preparation of microspheres for slow release drug by radiation-induced suspension polymerization and their properties", YAKUZAIGAKU, vol. 42, no. 3, 1982, pages 137 - 145
A.ARUN ET AL.: "In vitro drug release studies of 2-hydroxyethyl acrylate or 2-hydroxypropyl methacrylate-4-{(1E,4E)-5-[4-(acryloyloxy) phenyl]-3-oxopenta-1,4-dienyl)phenyl acrylate copolymer beads", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B: APPLIED BIOMATERIALS, vol. 73 B, no. 2, 2005, pages 291 - 300
TAKAYUKI TAKEI ET AL.: "Preparation of Polymeric Microspheres for Controlled Release of Acetamiprid", KAGAKU KOGAKU RONBUNSHU, vol. 39, no. 3, 20 July 2013 (2013-07-20), pages 219 - 223
E.JABBARI ET AL.: "Morphology of and release behavior from porous polyurethane microspheres", BIOMATERIALS, vol. 21, no. 20, 2000, pages 2073 - 2079
Attorney, Agent or Firm:
OKAMOTO, Hiroyuki et al. (JP)
Hiroyuki Okamoto (JP)
Hiroyuki Okamoto (JP)
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