Title:
EXTERNAL SECRETAGOGUE
Document Type and Number:
WIPO Patent Application WO/2019/208435
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing, for the purpose of symptomatic improvement of dry skin, dry eye, dry mouth, etc., an external secretagogue that promotes external secretions in a comprehensive manner and that can be utilized as a food composition, and more specifically, providing an agent that increases the moisture content of the horny cell layer, a saliva secretagogue, and a tear fluid secretagogue. Provided is an external secretagogue including a compound represented by a general formula (1) as an effective component. More specifically, provided is an agent that increases the moisture content in the horny cell layer, a saliva secretagogue, or a tear fluid secretagogue. (In general formula (1): R1-R4, R6 and R7 each denote a hydrogen atom or the like; R5 denotes a hydroxyl group or the like; and * denotes an asymmetric carbon atom.)
Inventors:
NISHIMACHI SAORI (JP)
IWAI TAKAO (JP)
MONOI NORIYUKI (JP)
IWAI TAKAO (JP)
MONOI NORIYUKI (JP)
Application Number:
PCT/JP2019/016825
Publication Date:
October 31, 2019
Filing Date:
April 19, 2019
Export Citation:
Assignee:
LION CORP (JP)
International Classes:
A23L33/10; A61K31/353; A61P1/02; A61P17/00; A61P27/02
Foreign References:
| US20140348966A1 | 2014-11-27 |
Other References:
ACHARYA, S ET AL.: "(2R,3S,2''R,3''R)-Manniflavanone Protects Proliferating Skeletal Muscle Cells against Oxidative Stress and Stimulates Myotube Formation", J AGRIC FOOD CHEM, vol. 65, no. 18, 2017, pages 3636 - 3646, XP055647862
STARK, TD ET AL.: "New highly in vitro antioxidative 3, 8''-linked Biflav(an)ones and Flavanone-C-glycosides from Garcinia buchananii stem bark", J AGRIC FOOD CHEM, vol. 61, no. 5, 2013, pages 12572 - 1281, XP055647877
STARK, TD ET AL.: "Isolation and structure elucidation of highly antioxidative 3,8''-linked biflavanones and flavanone-C-glycosides from Garcinia buchananii bark", J AGRIC FOOD CHEM, vol. 60, no. 8, 2012, pages 2053 - 2062, XP055647881
KRAFCZYK, N ET AL.: "Structure-antioxidant relationship of flavonoids from fermented rooibos", MOL NUTR FOOD RES, vol. 53, no. 5, 2009, pages 635 - 642, XP055647884
CHEN, YH ET AL.: "Identification of antioxidants from rhizome of Davallia solida", FOOD CHEMISTRY, vol. 107, no. 2, 2008, pages 684 - 691, XP022351966, DOI: 10.1016/j.foodchem.2007.08.066
KWON, JH ET AL.: "Antioxidative and anti-inflammatory effects of phenolic compounds from the roots of Ulmus macrocarpa", ARCH PHARM RES, vol. 34, no. 9, 2011, pages 1459 - 66, XP019961320
KWON, YS ET AL.: "Modulation of suppressive activity of lipopolysaccharide-induced nitric oxide production by glycosidation of flavonoids", ARCH PHARM RES, vol. 27, no. 7, 2004, pages 751 - 756, XP055647924
KAWAMURA MIHIRO, ET AL.: "Effect of hydrolysed royal jelly on rough skin (in vitro)", J SOC COSMET CHEM JPN, vol. 48, no. 1, 2014, pages 28 - 34
HUANG, JY ET AL.: "A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome", CLIN OPHTHALMOL, vol. 10, 2016, pages 813 - 820, XP055647927
RYO, K ET AL.: "Therapeutic effects of isoflavones on impaired salivary secretion", J CLIN BIOCHEM NUTR, vol. 55, no. 3, 2014, pages 168 - 173, XP055647929
STARK, TD ET AL.: "New highly in vitro antioxidative 3, 8''-linked Biflav(an)ones and Flavanone-C-glycosides from Garcinia buchananii stem bark", J AGRIC FOOD CHEM, vol. 61, no. 5, 2013, pages 12572 - 1281, XP055647877
STARK, TD ET AL.: "Isolation and structure elucidation of highly antioxidative 3,8''-linked biflavanones and flavanone-C-glycosides from Garcinia buchananii bark", J AGRIC FOOD CHEM, vol. 60, no. 8, 2012, pages 2053 - 2062, XP055647881
KRAFCZYK, N ET AL.: "Structure-antioxidant relationship of flavonoids from fermented rooibos", MOL NUTR FOOD RES, vol. 53, no. 5, 2009, pages 635 - 642, XP055647884
CHEN, YH ET AL.: "Identification of antioxidants from rhizome of Davallia solida", FOOD CHEMISTRY, vol. 107, no. 2, 2008, pages 684 - 691, XP022351966, DOI: 10.1016/j.foodchem.2007.08.066
KWON, JH ET AL.: "Antioxidative and anti-inflammatory effects of phenolic compounds from the roots of Ulmus macrocarpa", ARCH PHARM RES, vol. 34, no. 9, 2011, pages 1459 - 66, XP019961320
KWON, YS ET AL.: "Modulation of suppressive activity of lipopolysaccharide-induced nitric oxide production by glycosidation of flavonoids", ARCH PHARM RES, vol. 27, no. 7, 2004, pages 751 - 756, XP055647924
KAWAMURA MIHIRO, ET AL.: "Effect of hydrolysed royal jelly on rough skin (in vitro)", J SOC COSMET CHEM JPN, vol. 48, no. 1, 2014, pages 28 - 34
HUANG, JY ET AL.: "A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome", CLIN OPHTHALMOL, vol. 10, 2016, pages 813 - 820, XP055647927
RYO, K ET AL.: "Therapeutic effects of isoflavones on impaired salivary secretion", J CLIN BIOCHEM NUTR, vol. 55, no. 3, 2014, pages 168 - 173, XP055647929
Attorney, Agent or Firm:
SAKAI INTERNATIONAL PATENT OFFICE (JP)
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