Title:
EXTRACELLULAR RATIO-TYPE OXYGEN SENSING PROBE AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/103262
Kind Code:
A1
Abstract:
Provided in the present invention are a ratio-type oxygen sensing probe and a preparation method and a use thereof. The ratio-type oxygen sensing probe comprises a carrier and an oxygen-sensitive compound wrapped in the carrier. The carrier consists of an amphiphilic graft polymer and an aggregation-induced luminophore attached to the amphiphilic graft polymer. The ratio-type oxygen sensing probe of the present invention can measure the conditions of oxygen consumption of Escherichia coli and GM12878 human B lymphocyte under different cell concentrations, and in the meantime, the probe can measure in situ bacteria of at least 100 cfu/mL within 7 hours, and can also be used for drug screening, and has no cytotoxicity and is safe and reliable. In addition, since the PtTFPP probe micelle shows a extremely high quantum efficiency and the oxygen sensing probe can measure the oxygen content in an aqueous solution, the probe can be widely applied to some commercial instruments like a microplate reader, providing assistance to the high through-put measurement, disease diagnosis and metabolism research.
Inventors:
TIAN YANQING (CN)
ZOU XIANSHAO (CN)
PAN TINGTING (CN)
JIANG JIAPEI (CN)
ZOU XIANSHAO (CN)
PAN TINGTING (CN)
JIANG JIAPEI (CN)
Application Number:
PCT/CN2017/083205
Publication Date:
June 14, 2018
Filing Date:
May 05, 2017
Export Citation:
Assignee:
UNIV SOUTH SCIENCE & TECHNOLOGY CHINA (CN)
International Classes:
C09K11/06; C08F220/28; C08F220/58; C08F290/06; C09K11/02; G01N21/64
Foreign References:
| CN104974745A | 2015-10-14 | |||
| CN105440277A | 2016-03-30 | |||
| CN103951805A | 2014-07-30 | |||
| US20160349245A1 | 2016-12-01 |
Other References:
SU , FENGYU ET AL.: "Nanaostructured Oxygen Sensor-Using Micelles to Incorporate a Hydrophobic Platinum Porphyrin", PLOS ONE, vol. 7, 22 March 2012 (2012-03-22), pages 3, XP055491425
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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