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Title:
EXTRACELLULAR VESICLES DERIVED FROM RECOMBINANT MICROORGANISM INCLUDING POLYNUCLEOTIDE ENCODING TARGET PROTEIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/212293
Kind Code:
A1
Abstract:
Provided are extracellular vesicles (EVs) derived from a recombinant microorganism including one or more polynucleotides encoding one or more target proteins, extracellular vesicles isolated from the microorganism, and a use of the extracellular vesicles.

Inventors:
YUN, Ji Ae (707-1206, 100 Deogyeong-daero 1190beon-gil,,Gwonseon-gu, Suwon-si, Gyeonggi-do, 16662, KR)
JEONG, Hyun Uk (Rm.301, 20 Gyeongsu-daero 704beon-gil,,Paldal-gu, Suwon-si, Gyeonggi-do, 16233, KR)
CHOO, Jin Ho (2817-1802, 45 Sinsang-ro,,Bucheon-si, Gyeonggi-do, 14595, KR)
SONG, Soo Min (102-103, 82 Daeji-ro,,Suji-gu, Yongin-si, Gyeonggi-do, 16873, KR)
SONG, Ji Yoon (3-3 Seopangyo-ro 66beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13479, KR)
KIM, Yong In (201-2204, 19 Jeongjail-ro 213beon-gil,,Bundang-gu, Seongnam-si, Gyeonggi-do, 13556, KR)
CHO, Seung Kee (Rm.302, 36 Daehak 3-ro 4beon-gil,,Yeongtong-gu, Suwon-si, Gyeonggi-do, 16225, KR)
Application Number:
KR2019/005334
Publication Date:
November 07, 2019
Filing Date:
May 03, 2019
Export Citation:
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Assignee:
MEDYTOX INC. (78 Gangni 1-gil, Ochang-eup,Cheongwon-gu, Cheongju-si, Chungcheongbuk-do, 28126, KR)
International Classes:
A61K8/14; A61K8/64; A61K9/127; A61K38/18; A61K38/20; A61P17/00; A61Q19/00; A61Q19/02; C07K14/475
Foreign References:
KR20170015958A2017-02-10
KR19990064308A1999-07-26
KR20170038462A2017-04-07
KR101802980B12017-12-01
JP5354559B22013-11-27
Other References:
LI, M. ET AL.: "Lactobacillus-derived extracellular vesicles enhance host immune responses against vancomycin-resistant enterococci", BMC MICROBIOLOGY, vol. 17, 2017, pages 1 - 8, XP055441649, DOI: 10.1186/s12866-017-0977-7
BEHZADI, E. ET AL.: "The inhibitory impacts of Lactobacillus rhamnosus GG-derived extracellular vesicles on the growth of hepatic cancer cells", MICROBIAL PATHOGENESIS, vol. 110, 2017, pages 1 - 6, XP055648630
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (12F Daelim Acrotel, 13 Eonju-ro 30-gil,Gangnam-gu, Seoul, 06292, KR)
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