Title:
EXTRACELLULAR VESICLES DERIVED FROM RECOMBINANT CELLS INCLUDING POLYNUCLEOTIDE ENCODING IL-1 INHIBITOR AS TARGET PROTEIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/034131
Kind Code:
A1
Abstract:
The present invention relates to extracellular vesicles isolated from recombinant cells including a polynucleotide encoding an IL-1 inhibitor as a target protein, and use thereof.
Inventors:
YUN JI AE (KR)
CHO SEUNG KEE (KR)
JEONG HYUN UK (KR)
LIM SEON UNG (KR)
CHO SEUNG KEE (KR)
JEONG HYUN UK (KR)
LIM SEON UNG (KR)
Application Number:
PCT/KR2020/011137
Publication Date:
February 25, 2021
Filing Date:
August 20, 2020
Export Citation:
Assignee:
MEDYTOX INC (KR)
International Classes:
C12N1/20; A61K47/46; A61K48/00; A61P19/02; A61P19/06; C07K16/24; C12N1/16
Domestic Patent References:
| WO2018153581A1 | 2018-08-30 | |||
| WO2014168548A2 | 2014-10-16 |
Other References:
CHARLES A. DINARELLO, ANNA SIMON, JOS W. M. VAN DER MEER: "Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases", NATURE REVIEWS DRUG DISCOVERY, NATURE PUB. GROUP, vol. 11, no. 8, 1 August 2012 (2012-08-01), pages 633 - 652, XP055051238, ISSN: 14741776, DOI: 10.1038/nrd3800
GALIEVA LUISA R., JAMES VICTORIA, MUKHAMEDSHINA YANA O., RIZVANOV ALBERT A.: "Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders", FRONTIERS IN NEUROSCIENCE, vol. 13, XP055783139, DOI: 10.3389/fnins.2019.00163
YIM NAMBIN, RYU SEUNG-WOOK, CHOI KYUNGSUN, LEE KWANG RYEOL, LEE SEUNGHEE, CHOI HOJUN, KIM JEONGJIN, SHAKER MOHAMMED R., SUN WOONG,: "Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module", NATURE COMMUNICATIONS, vol. 7, no. 1, 1 November 2016 (2016-11-01), XP055783136, DOI: 10.1038/ncomms12277
GALIEVA LUISA R., JAMES VICTORIA, MUKHAMEDSHINA YANA O., RIZVANOV ALBERT A.: "Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders", FRONTIERS IN NEUROSCIENCE, vol. 13, XP055783139, DOI: 10.3389/fnins.2019.00163
YIM NAMBIN, RYU SEUNG-WOOK, CHOI KYUNGSUN, LEE KWANG RYEOL, LEE SEUNGHEE, CHOI HOJUN, KIM JEONGJIN, SHAKER MOHAMMED R., SUN WOONG,: "Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module", NATURE COMMUNICATIONS, vol. 7, no. 1, 1 November 2016 (2016-11-01), XP055783136, DOI: 10.1038/ncomms12277
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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