Title:
EYE DROP FOR TREATING EYE DRYNESS
Document Type and Number:
WIPO Patent Application WO/2018/205961
Kind Code:
A1
Abstract:
Disclosed in the present invention is an eye drop for treating eye dryness. With a pH value of 5.0-7.0, the eye drop consists of the following components in percentage by weight: 0.05-0.1% of an active component 5-hydroxy-1-beta-D-furanose-1H-imidazole-5-carboxamide, a proper amount of a pH value adjusting agent, 0.01-3% of an iso-osmotic agent, 0.003-0.5% of a bacteriostatic agent, 0.001-0.5% of a stabilizer, 0.01-0.5% of a tackifier, 2-5% of a solubilizer and the balance of water. The eye drop provided by the present invention can protect the epithelial barrier function of the corneas of a mouse with eye dryness and regain the number of goblet cells of the corneas, and can achieve relatively good anti-inflammatory and immune inhibition effects.
Inventors:
LIU ZUGUO (CN)
ZHANG XIAOBO (CN)
LIN XIANG (CN)
ZHANG XIAOBO (CN)
LIN XIANG (CN)
Application Number:
PCT/CN2018/086240
Publication Date:
November 15, 2018
Filing Date:
May 10, 2018
Export Citation:
Assignee:
UNIV XIAMEN (CN)
International Classes:
A61K9/08; A61K31/7056; A61K47/02; A61K47/04; A61K47/10; A61K47/18; A61K47/26; A61K47/36; A61P27/02
Foreign References:
| CN101528217A | 2009-09-09 | |||
| CN107049938A | 2017-08-18 | |||
| JPH07215881A | 1995-08-15 |
Other References:
XIAOBO ZHANG ET AL.: "Topical Application of Mizoribine Suppresses CD4+ T- cell - Mediated Pathogenesis in Murine Dry Eye", INVEST OPHTHALMOL VIS SCI., vol. 58, no. 14, 31 December 2017 (2017-12-31), pages 6056 - 6064, XP055612188, ISSN: 1552-5783
See also references of EP 3636252A4
See also references of EP 3636252A4
Attorney, Agent or Firm:
SHOUCHUANG JUNHE PATENT AGENT CO., LTD. XIAMEN (CN)
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