Title:
F-18 LABELED 5-AMINOLEVULINIC ACID DERIVATIVE, SYNTHESIS METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/087794
Kind Code:
A1
Abstract:
The present application discloses an F-18 labeled 5-aminolevulinic acid derivative, a synthesis method therefor, and an application thereof. A radioactive probe provided in an implementation of the present application has a long radioactive half-life, and the stability and fat solubility thereof are clearly higher than those of 5-aminolevulinic acid. Compared with 5-aminolevulinic acid, the F-18-labeled 5-aminolevulinic acid derivative can form higher concentrations in diseased tissues, while having lower concentrations and toxicity in normal tissues. Furthermore, because the fat-solubility of the derivative is better, the derivative has an improved ability to penetrate the blood-brain barrier, and can accurately locate tumor tissues throughout the body, and has the potential to be a broad-spectrum tumor imaging agent.
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Inventors:
ZHUANG XIAOQING (CN)
Application Number:
PCT/CN2019/073553
Publication Date:
May 07, 2020
Filing Date:
January 29, 2019
Export Citation:
Assignee:
ZHUANG XIAOQING (CN)
International Classes:
A61K51/04; C07C229/22; A61K101/02
Foreign References:
| CN109369433A | 2019-02-22 | |||
| CN101723850A | 2010-06-09 | |||
| US5856566A | 1999-01-05 |
Other References:
PIPPIN, ADAM B. ET AL.: "Radiochemical Synthesis and Evaluation of 13N-Labeled 5-Aminolevulinic Acid for PET Imaging of Gliomas", ACS MEDICINAL CHEMISTRY LETTERS, vol. 8, no. 12, 15 November 2017 (2017-11-15), pages 1236 - 1240, XP055699334, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.7b00311
Attorney, Agent or Firm:
CHINABLE IP (CN)
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