Title:
F-18-LABELED COMPOUND FOR POSITRON EMISSION TOMOGRAPHY OF DEAD CELLS AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/260483
Kind Code:
A1
Abstract:
The 18F-ApoPep-7 of chemical formula 1 according to the present invention, which is a derivative of 18F-ApoPep-1, has the manufacturing advantage of labeling the radioisotope F-18 with high radiochemical yield, radiochemical purify, and high specific radioactivity. Therefore, when used as an imaging drug for positron emission tomography, the 18F-ApoPep-7 of the present invention can be applied to the diagnosis of various diseases associated with apoptosis.
Inventors:
CHI DAE YOON (KR)
OH KEUMROK (KR)
OH KEUMROK (KR)
Application Number:
PCT/KR2022/008236
Publication Date:
December 15, 2022
Filing Date:
June 10, 2022
Export Citation:
Assignee:
SOGANG UNIV RESEARCH ＆ BUSINESS DEVELOPMENT FOUNDATION (KR)
International Classes:
A61K51/08; C07B59/00; C07K7/06; C07K7/64
Domestic Patent References:
| WO2016089187A1 | 2016-06-09 |
Other References:
REZAEIANPOUR SEDIGHEH, MOSAYEBNIA MONA, MOGHIMI ABOLGHASEM, AMIDI SALIMEH, GERAMIFAR PARHAM, KOBARFARD FARZAD, SHAHHOSSEINI SORAYA: "[ 18 F]FDG-Labeled CGPRPPC Peptide Serving as a Small Thrombotic Lesions Probe, Including a Comparison with [ 99m Tc]-Labeled Form", CANCER BIOTHERAPY & RADIOPHARMACEUTICALS, vol. 33, no. 10, 1 December 2018 (2018-12-01), US , pages 438 - 444, XP093014254, ISSN: 1084-9785, DOI: 10.1089/cbr.2018.2515
SU HA YEONG, SONI NISARG, HUYNH PHUONG TU, LEE BYUNG-HEON, AN GWANG IL, YOO JEONGSOO: "Comparative study of linear and cyclic forms of apoptosis-targeting peptide", JOURNAL OF RADIOPHARMACEUTICALS AND MOLECULAR PROBES, vol. 2, no. 2, 30 December 2016 (2016-12-30), pages 96 - 102, XP093014255, DOI: 10.22643/JRMP.2016.2.2.96
EVANS BRENDAN J., KING ANDREW T., KATSIFIS ANDREW, MATESIC LIDIA, JAMIE JOANNE F.: "Methods to Enhance the Metabolic Stability of Peptide-Based PET Radiopharmaceuticals", MOLECULES, vol. 25, no. 10, 1 January 2020 (2020-01-01), pages 11 - 15, XP055828495, DOI: 10.3390/molecules25102314
ZHANG PENGWEI, LINING XIE, JOHN W. BALLIET, DANILO R. CASIMIRO, FENG YAO: "A Herpes Simplex Virus 2 (HSV-2) Glycoprotein D-expressing Nonreplicating Dominant-Negative HSV-2 Virus Vaccine Is Superior to a gD2 Subunit Vaccine against HSV-2 Genital Infection in Guinea Pigs", PLOS ONE, vol. 9, no. 6, 30 June 2014 (2014-06-30), US , pages 1 - 9, XP093008390, ISSN: 1932-6203, DOI: 10.1371/journal.pone
OH KEUMROK, CHI DAE YOON: "Direct fluorination strategy for the synthesis of fluorine-18 labeled oligopeptide—[18F]ApoPep-7", BULL. KOREAN CHEM. SOC., vol. 42, no. 8, 1 August 2021 (2021-08-01), pages 1161 - 1166, XP093014261, ISSN: 1229-5949, DOI: 10.1002/bkcs.12350
SU HA YEONG, SONI NISARG, HUYNH PHUONG TU, LEE BYUNG-HEON, AN GWANG IL, YOO JEONGSOO: "Comparative study of linear and cyclic forms of apoptosis-targeting peptide", JOURNAL OF RADIOPHARMACEUTICALS AND MOLECULAR PROBES, vol. 2, no. 2, 30 December 2016 (2016-12-30), pages 96 - 102, XP093014255, DOI: 10.22643/JRMP.2016.2.2.96
EVANS BRENDAN J., KING ANDREW T., KATSIFIS ANDREW, MATESIC LIDIA, JAMIE JOANNE F.: "Methods to Enhance the Metabolic Stability of Peptide-Based PET Radiopharmaceuticals", MOLECULES, vol. 25, no. 10, 1 January 2020 (2020-01-01), pages 11 - 15, XP055828495, DOI: 10.3390/molecules25102314
ZHANG PENGWEI, LINING XIE, JOHN W. BALLIET, DANILO R. CASIMIRO, FENG YAO: "A Herpes Simplex Virus 2 (HSV-2) Glycoprotein D-expressing Nonreplicating Dominant-Negative HSV-2 Virus Vaccine Is Superior to a gD2 Subunit Vaccine against HSV-2 Genital Infection in Guinea Pigs", PLOS ONE, vol. 9, no. 6, 30 June 2014 (2014-06-30), US , pages 1 - 9, XP093008390, ISSN: 1932-6203, DOI: 10.1371/journal.pone
OH KEUMROK, CHI DAE YOON: "Direct fluorination strategy for the synthesis of fluorine-18 labeled oligopeptide—[18F]ApoPep-7", BULL. KOREAN CHEM. SOC., vol. 42, no. 8, 1 August 2021 (2021-08-01), pages 1161 - 1166, XP093014261, ISSN: 1229-5949, DOI: 10.1002/bkcs.12350
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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