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Title:
F-FUCOIDAN, DESULFATED F-FUCOIDAN, AND ITS PROCESSED DERIVATIVES IN TERMS OF DESULFATED OLIGO-FUCOSE AS INHIBITORS OF GASTROINTESTINAL INFECTION
Document Type and Number:
WIPO Patent Application WO/2019/074387
Kind Code:
A3
Abstract:
The subject of this invention are native forms of fucoidan polysaccharide, desulfated fucoidan and derivatives obtained by processing to the level of fucose-oligosaccarides containing preferentially, but not exclusively less than 20 monosaccaride fucose units alpha-linked by a glycosidic bond, with an average molecular weight of preferentially less than 3 kDa. The poly- and oligosaccarides that are described according to the invention are natural and safe, and are used as a dietary supplement for the use in prevention and treatment of pathologies associated with Noroviruses or Rotaviruses, Salmonella sp. or Pseudomonas aeruginosa or Campylobacter jejuni and other enteroviruses and enteric pathogens that cause bacterial gastroenteritis, as well as in the food production process. The invention also relates to a method for the desulfation and fragmentation of fucoidans to generate desulfated poly- or oligo-fucoses.

Inventors:
PAVLOVIC BOJAN (RS)
HANISCH FRANZ-GEORG (DE)
AYDOGAN CEM (CH)
Application Number:
PCT/RS2018/000016
Publication Date:
May 31, 2019
Filing Date:
October 05, 2018
Export Citation:
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Assignee:
PAVLOVIC BOJAN (RS)
HANISCH FRANZ GEORG (DE)
AYDOGAN CEM (CH)
International Classes:
C08B37/00; A61P31/04; A61P31/12
Foreign References:
JP2010119352A2010-06-03
Other References:
LONG YU ET AL: "Enzymatic preparation and structural determination of oligosaccharides derived from sea cucumber (Acaudina molpadioides) fucoidan", FOOD CHEMISTRY, vol. 139, no. 1-4, 1 August 2013 (2013-08-01), NL, pages 702 - 709, XP055572893, ISSN: 0308-8146, DOI: 10.1016/j.foodchem.2013.01.055
PIELESZ A ET AL: "Mild acid hydrolysis of fucoidan: characterization by electrophoresis and FT-Raman spectroscopy", CARBOHYDRATE RESEARCH, PERGAMON, GB, vol. 346, no. 13, 14 May 2011 (2011-05-14), pages 1937 - 1944, XP028277364, ISSN: 0008-6215, [retrieved on 20110530], DOI: 10.1016/J.CARRES.2011.05.016
FERIAL HAROUN-BOUHEDJA ET AL: "Relationship between Sulfate Groups and Biological Activities of Fucans", THROMBOSIS RESEARCH, vol. 100, no. 5, 1 December 2000 (2000-12-01), US, pages 453 - 459, XP055574096, ISSN: 0049-3848, DOI: 10.1016/S0049-3848(00)00338-8
LI BO ET AL: "Fucoidan: structure and bioactivity", MOLECULES: A JOURNAL OF SYNTHETIC ORGANIC AND NATURAL PRODUCT CHEMISTRY, M D P I AG, CH, vol. 13, no. 8, 12 August 2008 (2008-08-12), pages 1671 - 1695, XP002574600, ISSN: 1420-3049, DOI: 10.3390/MOLECULES13081671
DATABASE WPI Week 201038, Derwent World Patents Index; AN 2010-G04284, XP002790067
Attorney, Agent or Firm:
PAVLOVIC, Bojan (RS)
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