F11 RECEPTOR(F11R) ANTAGONISTS AS THERAPEUTIC AGENTS

Title:

F11 RECEPTOR(F11R) ANTAGONISTS AS THERAPEUTIC AGENTS

Document Type and Number:

WIPO Patent Application WO2004063327

Kind Code:

A3

Abstract:

The present invention provides a cell adhesion molecule (CAM), designated F11 receptor (F11R), which is a member of the immunoglobulin super family localized on the surface of human platelets, and determined to effect platelet aggregation, secretion, platelet spreading and cellular adhesion. Cloned F11R cDNA and full length F11R cDNA and amino acid sequences are provided. F11R-antagonists and methods for the prevention and treatment of thrombosis, heart attacks, stroke and other clinical disorders involving thrombus formation are also provided.

Inventors:

KORNECKI ELIZABETH (US)
BABINSKA ANNA (US)
EHRLICH YIGAL H (US)

Application Number:

PCT/US2003/039890

Publication Date:

April 21, 2005

Filing Date:

December 16, 2003

Export Citation:

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Assignee:

KORNECKI ELIZABETH (US)
BABINSKA ANNA (US)
EHRLICH YIGAL H (US)

International Classes:

C07K14/705; (IPC1-7): C07K1/00; A01N37/18

Foreign References:

US6358707B1	2002-03-19
US6699688B1	2004-03-02

Other References: