Title:
FATTY ACYL-CoA: FATTY ALCOHOL O-ACYLTRANSFERASES
Document Type and Number:
WIPO Patent Application WO/1993/010241
Kind Code:
A1
Abstract:
By this invention, a partially purified fatty acyl-CoA: fatty alcohol acyltransferase (wax synthase) is provided, wherein said protein is active in the formation of a wax ester from fatty alcohol and fatty acyl substrates. Of special interest is a jojoba embryo wax synthase having an apparent molecular mass of approximately 57kD. Also considered are amino acid and nucleic acid sequences obtainable from wax synthase proteins and the use of such sequences to provide transgenic host cells capable of producing wax esters.
Inventors:
METZ JAMES GEORGE (US)
LARDIZABAL KATHRYN DENNIS (US)
LASSNER MICHAEL W (US)
LARDIZABAL KATHRYN DENNIS (US)
LASSNER MICHAEL W (US)
Application Number:
PCT/US1992/009863
Publication Date:
May 27, 1993
Filing Date:
November 13, 1992
Export Citation:
Assignee:
CALGENE INC (US)
International Classes:
C12N5/00; C12N5/10; C12N9/02; C12N9/10; C12N15/00; C12N15/05; C12N15/09; C12N15/54; C12N15/82; C12P7/64; C12R1/91; (IPC1-7): C12N9/02; C12N9/10; C12N15/05; C12N15/54; C12N15/82; C12P7/64
Other References:
ABSTRACT FROM THE SOUTHWEST CONSORTIUM ON PLANT GENETICS AND WATER RESOURCES, 5TH ANNUAL MEETING April 1990, LAS CRUCES NM GUNTER F. WILDNER ET AL. 'Wax ester biosynthesis in euglena gracilis' cited in the application
LIPIDS vol. 14, no. 7, 1979, pages 651 - 662 MICHAEL R. POLLARD ET AL. 'Studies on biosynthesis of waxes by developing Jojoba seed. II.The demonstration of wax biosynthesis by cell-free homogenates' cited in the application
JOURNAL OF LIPID RESEARCH vol. 27, no. 4, April 1986, pages 404 - 411 P.E. KOLATTUKUDY ET AL. 'Acyl-CoA reductase and acyl-CoA: fatty alcohol acyl tranferase in the microsomal preparation from the bovine meibomian gland'
LIPIDS vol. 14, no. 7, 1979, pages 651 - 662 MICHAEL R. POLLARD ET AL. 'Studies on biosynthesis of waxes by developing Jojoba seed. II.The demonstration of wax biosynthesis by cell-free homogenates' cited in the application
JOURNAL OF LIPID RESEARCH vol. 27, no. 4, April 1986, pages 404 - 411 P.E. KOLATTUKUDY ET AL. 'Acyl-CoA reductase and acyl-CoA: fatty alcohol acyl tranferase in the microsomal preparation from the bovine meibomian gland'
Attorney, Agent or Firm:
Lassen, Elizabeth (Inc., 1920 Fifth Street, Davis, CA, US)
Download PDF:
Previous Patent: beta-KETOACYL-ACP SYNTHETASE II GENES FROM PLANTS
Next Patent: RECOMBINANT GASTRIC RABBIT LIPASE AND PHARMACEUTICAL COMPOSITIONS
Next Patent: RECOMBINANT GASTRIC RABBIT LIPASE AND PHARMACEUTICAL COMPOSITIONS