Title:
FABRICATION AND EVALUATION OF DENTIN POWDER SURFACE MODIFIED WITH ALGINATE ON PROLIFERATION OF DENTAL PULP STEM CELLS (IN VITRO) AND REGENERATION OF DENTIN ORGAN AND IMMUNOGENICITY (IN VIVO)
Document Type and Number:
WIPO Patent Application WO/2023/135481
Kind Code:
A1
Abstract:
This invention is about the fabrication and evaluation of dentin powder surface modified with alginate on the proliferation of dental pulp stem cells (in vitro) and also the regeneration of dentin organs and immunogenicity (in vivo) root canal treatment of necrosis, traumatized or extended decayed. so we make material to promote dentin-pulp-like tissue to complete the maturation of the apex and thickening wall of the root which degraded during this procedure. the result indicates that surface modification of demineralized dentin powders with alginate is beneficial to improve the mechanical properties of the surface and shows better biocompatibility and minimum immunogenicity which can be used for dentin-pulp-like tissue.
Inventors:
MANZARPOUR MELIKA (IR)
BAKHTIAR HENGAMEH (IR)
BAKHTIAR HENGAMEH (IR)
Application Number:
PCT/IB2022/062774
Publication Date:
July 20, 2023
Filing Date:
December 25, 2022
Export Citation:
Assignee:
MANZARPOUR MELIKA (IR)
International Classes:
C12N5/0775; A61K35/00
Domestic Patent References:
| WO2006116530A2 | 2006-11-02 |
Other References:
ATHIRASALA AVATHAMSA, TAHAYERI ANTHONY, THRIVIKRAMAN GREESHMA, FRANÇA CRISTIANE M, MONTEIRO NELSON, TRAN VICTOR, FERRACANE JACK, B: "A dentin-derived hydrogel bioink for 3D bioprinting of cell laden scaffolds for regenerative dentistry", BIOFABRICATION, vol. 10, no. 2, pages 024101, XP093080629, DOI: 10.1088/1758-5090/aa9b4e
HOLIEL AHMED: "Regenerative Potential Of A Novel Treated Dentin Matrix Hydrogel In Pulp Capping", CONFERENCE: 2020 IADR/AADR/CADR GENERAL SESSION, 1 January 2020 (2020-01-01), XP093080627
BAKHTIAR HENGAMEH; MAZIDI AMIR; MOHAMMADI-ASL SAEED; HASANNIA SADEGH; ELLINI MOHAMMAD REZA; PEZESHKI-MODARESS MOHAMMAD; OSTAD SEYE: "Potential of Treated Dentin Matrix Xenograft for Dentin-Pulp Tissue Engineering", JOURNAL OF ENDODONTICS, ELSEVIER, AMSTERDAM, NL, vol. 46, no. 1, 20 November 2019 (2019-11-20), AMSTERDAM, NL , pages 57, XP085947498, ISSN: 0099-2399, DOI: 10.1016/j.joen.2019.10.005
KANAFI ET AL.: "Dental pulp stem cells immobilized in alginate microspheres for applications in bone tissue engineering", INTERNATIONAL ENDODONTIC JOURNAL, vol. 47, 7 July 2014 (2014-07-07), pages 687 - 697, XP071472299, DOI: 10.1111/iej.12205
HOLIEL AHMED: "Regenerative Potential Of A Novel Treated Dentin Matrix Hydrogel In Pulp Capping", CONFERENCE: 2020 IADR/AADR/CADR GENERAL SESSION, 1 January 2020 (2020-01-01), XP093080627
BAKHTIAR HENGAMEH; MAZIDI AMIR; MOHAMMADI-ASL SAEED; HASANNIA SADEGH; ELLINI MOHAMMAD REZA; PEZESHKI-MODARESS MOHAMMAD; OSTAD SEYE: "Potential of Treated Dentin Matrix Xenograft for Dentin-Pulp Tissue Engineering", JOURNAL OF ENDODONTICS, ELSEVIER, AMSTERDAM, NL, vol. 46, no. 1, 20 November 2019 (2019-11-20), AMSTERDAM, NL , pages 57, XP085947498, ISSN: 0099-2399, DOI: 10.1016/j.joen.2019.10.005
KANAFI ET AL.: "Dental pulp stem cells immobilized in alginate microspheres for applications in bone tissue engineering", INTERNATIONAL ENDODONTIC JOURNAL, vol. 47, 7 July 2014 (2014-07-07), pages 687 - 697, XP071472299, DOI: 10.1111/iej.12205
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