FABRICATION OF A HIGH RESOLUTION BIOLOGICAL MOLECULE DETECTION DEVICE WITH GOLD ELECTRICAL CONDUCTORS

WIPO Patent Application WO2004042344

A3

The present invention relates to a method of manufacturing a detection device which involves providing a substrate having a layer of gold and a first layer of photosensitive material. Next, the substrate is subjected to a first level photolithography treatment to produce a gold electrical conductor containing conductive fingers with spaces between them. Finally, biological probes are attached to the conductive fingers under conditions effective to form a gap between the biological probes on the spaced apart conductive fingers. As a result, a target molecule, if present in a sample, can bind to a pair of the biological probes on the spaced apart conductive fingers to bridge the gap between the biological probes, allowing detection of the target molecule.

WO2001034130	THERAPY FOR HUMAN CANCERS USING CISPLATIN AND OTHER DRUGS OR GENES ENCAPSULATED INTO LIPOSOMES
JP5973425	A manufacturing method of the phosphoric acid compound which has a corresponding object
WO/2003/078626	A BUILDING BLOCK CAPABLE OF TRANSFERRING A FUNCTIONAL ENTITY

PHAM HONG-AN (US)
CONNOLLY DENNIS M (US)

PCT/US2002/036650

December 16, 2004

November 14, 2002

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INTEGRATED NANO TECH LLC (US)
PHAM HONG-AN (US)
CONNOLLY DENNIS M (US)

C07H21/02; C07H21/04; C12Q1/68; C25D3/04; C25D3/48; C25D5/00; G01N33/543; G03C5/00; C40B40/06; G01N; (IPC1-7): C25D5/00; C07H21/02; C07H21/04; C12Q1/68; C25D3/04; C25D3/48; G03C5/00

US5318687A	1994-06-07
US5679888A	1997-10-21
US5350944A	1994-09-27

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