Title:
FACILITATED FORWARD CHEMICAL GENETICS USING TAGGED TRIAZINE LIBRARY
Document Type and Number:
WIPO Patent Application WO2004099106
Kind Code:
A3
Abstract:
A novel tagged triazine library is provided in which three building blocks are prepared separately and assembled orthogonally to yield 1536 highly pure compounds. Each library compound contains a variety of a triethyleneglycol (TG) linker t one of the diversity sites of the triazine scaffold.
Inventors:
CHANG YOUNG-TAE (US)
Application Number:
PCT/US2004/013898
Publication Date:
February 24, 2005
Filing Date:
May 05, 2004
Export Citation:
Assignee:
UNIV NEW YORK (US)
CHANG YOUNG-TAE (US)
CHANG YOUNG-TAE (US)
International Classes:
C07D251/44; G01N33/543; G01N33/68; C07B61/00; (IPC1-7): G02D251/12; G01N33/543
Domestic Patent References:
| WO2003050237A2 | 2003-06-19 | |||
| WO2003032903A2 | 2003-04-24 |
Other References:
SCHARN D ET AL: "Spatially addressed synthesis of amino- and amino-oxy- substituated 1,3,5-triazine arrays on polymeric membranes", JOURNAL OF COMBINATORIAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 2, June 2000 (2000-06-01), pages 361 - 369, XP002241441, ISSN: 1520-4766
SILEN JOY L ET AL: "Screening for novel antimicrobials from encoded combinatorial libraries by using a two-dimensional agar format", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 42, no. 6, June 1998 (1998-06-01), pages 1447 - 1453, XP002203675, ISSN: 0066-4804
GUSTAFSON G R ET AL: "Incorporation of Carbohydrates and Peptides into Large Triazine-Based Screening Libraries Using Automated Parallel Synthesis", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 54, no. 16, 16 April 1998 (1998-04-16), pages 4051 - 4065, XP004162179, ISSN: 0040-4020
S. M. KHERSONSKY ET AL: "Facilitated forward chemical genetics using a tagged triazine library and zebrafish embryo screening", J.AM.CHEM.SOC., vol. 125, no. 39, 9 September 2003 (2003-09-09), pages 11804 - 11805, XP002301137
MOON H-S ET AL: "A Novel Microtubule Destabilizing Entity from Orthogonal Synthesis of a Triazine Library and Zebrafish Embryo Screening", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 124, 2002, pages 11608 - 11609, XP002297373, ISSN: 0002-7863
SCHREIBER S L: "CHEMICAL GENETICS RESULTING FROM A PASSION FOR SYNTHETIC ORGANIC CHEMISTRY", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 6, 1998, pages 1127 - 1152, XP002950111, ISSN: 0968-0896
CREWS C M ET AL: "Chemical genetics: exploring and controlling cellular processes with chemical probes", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 24, no. 8, 1 August 1999 (1999-08-01), pages 317 - 320, XP004174252, ISSN: 0968-0004
SILEN JOY L ET AL: "Screening for novel antimicrobials from encoded combinatorial libraries by using a two-dimensional agar format", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 42, no. 6, June 1998 (1998-06-01), pages 1447 - 1453, XP002203675, ISSN: 0066-4804
GUSTAFSON G R ET AL: "Incorporation of Carbohydrates and Peptides into Large Triazine-Based Screening Libraries Using Automated Parallel Synthesis", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 54, no. 16, 16 April 1998 (1998-04-16), pages 4051 - 4065, XP004162179, ISSN: 0040-4020
S. M. KHERSONSKY ET AL: "Facilitated forward chemical genetics using a tagged triazine library and zebrafish embryo screening", J.AM.CHEM.SOC., vol. 125, no. 39, 9 September 2003 (2003-09-09), pages 11804 - 11805, XP002301137
MOON H-S ET AL: "A Novel Microtubule Destabilizing Entity from Orthogonal Synthesis of a Triazine Library and Zebrafish Embryo Screening", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 124, 2002, pages 11608 - 11609, XP002297373, ISSN: 0002-7863
SCHREIBER S L: "CHEMICAL GENETICS RESULTING FROM A PASSION FOR SYNTHETIC ORGANIC CHEMISTRY", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 6, 1998, pages 1127 - 1152, XP002950111, ISSN: 0968-0896
CREWS C M ET AL: "Chemical genetics: exploring and controlling cellular processes with chemical probes", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 24, no. 8, 1 August 1999 (1999-08-01), pages 317 - 320, XP004174252, ISSN: 0968-0004
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