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Title:
FACTOR VIIA INHIBITORY (THIO)UREA DERIVATIVES, THEIR PREPARATION AND THEIR USE
Document Type and Number:
WIPO Patent Application WO2001094301
Kind Code:
A3
Abstract:
The present invention relates to compounds of formula (I), in which R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, A, X, m and n have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of thromboembolic diseases and restenoses. They are reversible inhibitors of the blood clotting enzyme factor VIIa and can in general be applied in conditions in which an undesired activity of factor VIIa is present or for the cure or prevention of which an inhibition of factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

Inventors:
KLINGLER OTMAR
SCHUDOK MANFRED
NESTLER HANS-PETER
MATTER HANS
SCHREUDER HERMAN
Application Number:
EP0106029W
Publication Date:
April 04, 2002
Filing Date:
May 26, 2001
Export Citation:
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Assignee:
AVENTIS PHARMA DEUTSCHLAND GMBH
International Classes:
C07D319/16; A61K31/17; A61K31/357; A61K31/426; A61K31/4409; A61K31/4465; A61K31/5375; A61K31/538; A61P7/00; A61P7/02; A61P43/00; C07C273/02; C07C275/40; C07C275/42; C07C275/64; C07C303/40; C07C311/05; C07C311/18; C07C315/04; C07C317/32; C07D211/78; C07D211/96; C07D213/40; C07D265/38; C07D277/20; C07D277/46; C07D319/18; (IPC1-7): C07C275/42; C07D211/96; A61K31/17; A61P7/00; C07D213/40; C07D319/18; C07D211/62; C07D213/82; C07C311/13; C07D277/54; C07C311/08; C07D319/20; C07D295/135
Domestic Patent References:
WO1994017041A11994-08-04
WO1994022907A11994-10-13
Foreign References:
EP0987274A12000-03-22
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