FAST - INDEXING FILTER WHEEL AND ITS USE IN A NUCLEIC ACID SEQUENCING SYSTEM

WIPO Patent Application WO/2011/026141

A3

Various embodiments of a sequencing system capable of rapidly imaging samples at multiple wavelengths are provided herein. In one embodiment, the system includes a fast- indexing filter wheel having a plurality of excitation and emission filters capable of being rapidly rotated into and out of communication with an excitation source (e.g., an arc lamp, a laser). For example, the filter wheel can be configured to index in an amount of time falling within a range of about 40 ms to about 60 ms, preferably 50 ms. The system can also be configured to account for vibrations resulting from the quick starts and stops of the fast- indexing filter wheel as well as vibrations resulting from other sources. Various methods of rapidly imaging a sample at multiple wavelength are also provided herein.

COX DAVID (US)
HABERSTROH MARC (US)
KINNEY PATRICK D (US)
CARRILLO ALBERT L (US)
HOSHIZAKI JON A (US)
SHARIATI MARYAM (US)
KING HOWARD G (US)
LEE JOE Y (US)
CHAN MATTHEW S (US)

PCT/US2010/047402

April 21, 2011

August 31, 2010

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LIFE TECHNOLOGIES CORP (US)
COX DAVID (US)
HABERSTROH MARC (US)
KINNEY PATRICK D (US)
CARRILLO ALBERT L (US)
HOSHIZAKI JON A (US)
SHARIATI MARYAM (US)
KING HOWARD G (US)
LEE JOE Y (US)
CHAN MATTHEW S (US)

G02B7/00; B01F33/40; G02B21/00

LUDL ELECTRONIC PRODUCTS LTD.: "Filter Wheels-High Performance Filter Changers for Quantitative Microscopy", 19 February 2005 (2005-02-19), XP002608551, Retrieved from the Internet [retrieved on 20101108]

DOYLE, Michael (c/o IntelelvateP.O. Box 5205, Minneapolis Minnesota, US)

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